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We therefore investigated the associations between genetic polymorphisms in the DNA repair genes <jats:italic>XRCC1 (Arg194Trp<\/jats:italic> and <jats:italic>Arg399Gln<\/jats:italic>) and <jats:italic>XPD (Asp312Asn<\/jats:italic> and <jats:italic>Lys751Gln<\/jats:italic>) and risk of ESCC in an at\u2010risk Chinese population. Genotypes were determined by a PCR\u2010based approach in 433 patients with ESCC and 524 frequency\u2010matched normal controls. We found that individuals with <jats:italic>Trp\/Trp<\/jats:italic> genotype at <jats:italic>XRCC1 Arg194Trp<\/jats:italic> site had a 2\u2010fold increased risk of this disease compared to <jats:italic>Arg\/Arg<\/jats:italic> genotype (adjusted OR = 1.98; 95% CI 1.26\u20133.12). Furthermore, when compared to <jats:italic>Arg\/Arg<\/jats:italic> and <jats:italic>Arg\/Trp<\/jats:italic> genotype combined, homozygote for <jats:italic>Trp\/Trp<\/jats:italic> genotype significantly increased the risk of developing ESCC, with the adjusted OR being 2.07 (95% CI 1.34\u20133.20). However, the <jats:italic>XRCC1 Arg399Gln<\/jats:italic> polymorphism was not significantly associated with risk of ESCC, with the adjusted OR being 0.87 (95% CI 0.55\u20131.37). Neither <jats:italic>Asp312Asn<\/jats:italic> nor <jats:italic>Lys751Gln<\/jats:italic> polymorphisms in the <jats:italic>XPD<\/jats:italic> gene influenced risk of ESCC in our study. These findings suggest that DNA repair gene <jats:italic>XRCC1<\/jats:italic> but not <jats:italic>XPD<\/jats:italic> might play a role in esophageal carcinogenesis and might represent a genetic determinant in the development of the cancer. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10528","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:05:28Z","timestamp":1031709928000},"page":"600-605","source":"Crossref","is-referenced-by-count":96,"title":["Polymorphisms of DNA repair genes <i>XRCC1<\/i> and <i>XPD<\/i> and their associations with risk of esophageal squamous cell carcinoma in a Chinese 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