{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:29:30Z","timestamp":1782185370310,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,7,16]],"date-time":"2002-07-16T00:00:00Z","timestamp":1026777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Europe Against Cancer Programme","award":["SOC96-200505-05F02"],"award-info":[{"award-number":["SOC96-200505-05F02"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RO1 AI43868"],"award-info":[{"award-number":["RO1 AI43868"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concentration of T\u2010cell receptor rearrangement excision DNA circles (TRECs) in peripheral blood mononuclear cells (PBMCs) is currently known to be a marker of recent thymic emigrants. We evaluated the hypothesis that TREC values would be lower in childhood T\u2010cell hematopoietic malignancies than in childhood B\u2010cell acute lymphoblastic leukemia (ALL) or healthy controls because the former category may reflect compromised thymic function. From the Greek national childhood leukemia\/lymphoma database we obtained all 30 available T\u2010cell leukemia\/non\u2010Hodgkin's lymphoma cases, 30 age\u2010 and sex\u2010matched childhood B\u2010cell origin cases of ALL and 60 healthy hospital controls. We compared TREC levels in PBMCs using a real\u2010time PCR assay. There was highly significant reduction of TREC values in children with T\u2010cell malignancies (median 3,100 TRECs\/10<jats:sup>6<\/jats:sup> PBMCs), whereas children with B\u2010cell origin ALL had slightly but nonsignificantly lower TREC values compared to healthy children (medians 19,300 and 22,500 TRECs\/10<jats:sup>6<\/jats:sup> PBMCs, respectively). During a median follow\u2010up period of about 19 months, only 4 children died. All of them had a T\u2010cell hematopoietic malignancy and relatively low TREC values. The number of TRECs was higher among healthy girls than among healthy boys, and a similar pattern was evident in T\u2010cell malignancies. It appears that there is a pattern of concordance of high TREC values with better disease prognosis in hematologic childhood malignancies. This applies to specific disease entities with better prognosis (B\u2010cell origin ALL having higher TREC values than T\u2010cell leukemia\/lymphoma) and to gender, another important predictor of prognosis conditional on disease entity (girls having higher TREC values than boys); however, it may also be true for the survival of individual patients. These preliminary findings can be used as hypothesis\u2010generating indications that should be confirmed in larger data sets. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10568","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:56:23Z","timestamp":1033905383000},"page":"74-77","source":"Crossref","is-referenced-by-count":20,"title":["Recent thymic emigrants and prognosis in T\u2010 and B\u2010cell childhood hematopoietic malignancies"],"prefix":"10.1002","volume":"101","author":[{"given":"Eleni","family":"Petridou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Klimentopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moustaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontios G.","family":"Kostrikis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos","family":"Hatzakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Trichopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Hellenic Pediatric Hematology Oncology Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80462-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1536"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/23791"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.5.725"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)10311-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270937"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.4049\/jimmunol.161.11.5909","article-title":"IL\u20107 dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire","volume":"161","author":"Soares M","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_9_2","first-page":"1012","volume-title":"Hematology of infancy and childhood","author":"Korsmeyer SJ","year":"1993"},{"key":"e_1_2_6_10_2","first-page":"1249","volume-title":"Hematology of infancy and childhood","author":"Niemeyer CM","year":"1993"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.245"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.541"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<345::AID-IJC7>3.0.CO;2-#"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.133"},{"key":"e_1_2_6_15_2","first-page":"2542","article-title":"Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion","volume":"61","author":"Alexander FE","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_2","first-page":"1319","volume-title":"Hematology of infancy and childhood","author":"Link PM","year":"1993"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80056-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910143411610"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/25251"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.4049\/jimmunol.156.7.2369","article-title":"Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes","volume":"156","author":"Ciernik IF","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050443"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1069(199708)15:3<129::AID-HON607>3.0.CO;2-N"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02255855"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.18388\/abp.1999_4121","article-title":"Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination","volume":"46","author":"Brillowska A","year":"1999","journal-title":"Acta Biochim Pol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.1.3823458"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.269"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841858909174677"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01958950"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/79549"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10568","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:07:08Z","timestamp":1694714828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,25]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/ijc.10568"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10568","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,25]]}}}