{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:39:19Z","timestamp":1761057559752},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T00:00:00Z","timestamp":1031011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Comunidad Autonoma de Madrid","award":["08.1\/0020.1\/00","08.1\/0013\/00","MEC-PM99\/0003"],"award-info":[{"award-number":["08.1\/0020.1\/00","08.1\/0013\/00","MEC-PM99\/0003"]}]},{"name":"Pharmaceutical College"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>p73<\/jats:italic> is a candidate tumor suppressor and imprinted gene that shares significant homology with the <jats:italic>p53<\/jats:italic> gene. It is located on 1p36, a region frequently deleted in neuroblastoma and other tumors. To investigate the pattern of inactivation of this gene in human lymphomas, we studied 59 tumors to identify abnormal methylation in exon 1 and loss of heterozygosity (LOH) at this locus. <jats:italic>p73<\/jats:italic> was methylated in 13\/50 (26%) B cell lymphomas. There was no evidence of <jats:italic>p73<\/jats:italic> methylation in the 9 T cell lymphomas analyzed. Burkitt's lymphomas showed the highest proportion of methylated cases (36%), although this alteration also affected other aggressive lymphomas such as diffuse large cell and some marginal zone lymphomas. LOH at the <jats:italic>p73<\/jats:italic> locus was detected in 4\/34 (11%) B and 1\/9 (11%) T cell lymphomas. The <jats:italic>p73<\/jats:italic> expression analysis showed absence or low level of <jats:italic>p73<\/jats:italic> product in methylated lymphomas, whereas <jats:italic>p73<\/jats:italic> was always detected in unmethylated tumors. We found monoallelic expression in normal peripheral blood samples, consistent with imprinting. None of the tumors showed LOH and methylation of the remaining allele simultaneously, suggesting that alteration of the expressed allele could lead to the total inactivation of the gene. Our results show that deletion or methylation of the <jats:italic>p73<\/jats:italic> gene could be important mechanisms in suppressing <jats:italic>p73<\/jats:italic> expression in B cell non\u2010Hodgkin's lymphomas. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10618","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:28:15Z","timestamp":1034137695000},"page":"15-19","source":"Crossref","is-referenced-by-count":49,"title":["Frequent inactivation of the <i>p73<\/i> gene by abnormal methylation or LOH in non\u2010Hodgkin's lymphomas"],"prefix":"10.1002","volume":"102","author":[{"given":"Beatriz","family":"Martinez\u2010Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Melendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Cuadros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Jose 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