{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:22:59Z","timestamp":1789428179012,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,8,13]],"date-time":"2002-08-13T00:00:00Z","timestamp":1029196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cadherins represent a family of calcium\u2010dependent cell adhesion molecules with an important regulatory function for maintenance of tissue architecture. Alterations of cadherin expression have been demonstrated in the development and progression of different epithelial tumors. In renal cell carcinoma (RCC), the majority of tumors express N\u2010cadherin and cadherin\u20106. Screening a series of 16 RCC cell lines for the expression of different novel type II cadherins by RT\u2010PCR revealed a complex pattern of cadherin expression: cadherins 6 and 14 were expressed in most of the RCC cell lines, whereas cadherins 11, 12 and 13 could not be detected at all. Interestingly, cadherin\u20108, previously shown in mice to be restricted to the CNS and thymus during development, was detected by RT\u2010PCR, immunofluorescence and <jats:italic>in situ<\/jats:italic> hybridization in 4 of 16 RCC cell lines as well as in paraffin sections of the corresponding human RCC biopsies. In normal renal tissue, however, cadherin\u20108 could be detected only during the early stages of kidney development. These results suggest that alterations of type II cadherin expression may play a role in RCC development. In particular, cadherin\u20108 may be involved in both kidney morphogenesis as well as tumorigenesis in some types of RCC. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10623","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T23:02:11Z","timestamp":1034118131000},"page":"327-334","source":"Crossref","is-referenced-by-count":19,"title":["Expression of cadherin\u20108 in renal cell carcinoma and fetal kidney"],"prefix":"10.1002","volume":"101","author":[{"given":"Sabine","family":"Blaschke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Markovic\u2010Lipkovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Puch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Miosge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard A.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"214","article-title":"Epithelial tumors of the adult kidney: evaluation of the current diagnostic and prognostic criteria","volume":"4","author":"Santinelli A","year":"2000","journal-title":"Adv Clin Pathol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970901)80:5<987::AID-CNCR24>3.0.CO;2-R"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00708.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.4.629"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03249.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(93)90250-L"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006200102166"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80122-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.2.4.261"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/15419069409014199"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5152"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199702)208:2<178::AID-AJA5>3.0.CO;2-F"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00077-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.17.11987"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj3490159","article-title":"Identification of three human type II classic cadherins and frequent heterophilic interactions between different subclasses of type II classic cadherins","volume":"349","author":"Shimoyama Y","year":"2000","journal-title":"Biochem J"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4682(10)80011-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.1999.0155"},{"key":"e_1_2_6_19_2","first-page":"3929","article-title":"Decreased E\u2010cadherin expression is associated with poor prognosis in patients with prostate cancer","volume":"54","author":"Umbas R","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_6_20_2","first-page":"2185","article-title":"Expression of E\u2010 and P\u2010cadherin in gastric carcinomas","volume":"51","author":"Shimoyama Y","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.21140"},{"key":"e_1_2_6_22_2","first-page":"3234","article-title":"Complex cadherin expression in renal cell carcinoma","volume":"56","author":"Shimazui T","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_23_2","first-page":"2741","article-title":"Cadherin\u20106, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma","volume":"57","author":"Paul R","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.225"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000020302"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<160::AID-IJC23>3.0.CO;2-M"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.8.5236"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.10011"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/15419069509081281"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200006)191:2<162::AID-PATH604>3.0.CO;2-8"},{"key":"e_1_2_6_31_2","first-page":"3034","article-title":"Isolation of complementary DNA encoding K\u2010cadherin, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma","volume":"54","author":"Xiang YY","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.5.803"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9738"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(85)90135-6"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64829-8"},{"key":"e_1_2_6_36_2","first-page":"895","article-title":"Expression of the human nephron differentiation molecules in renal cell carcinomas","volume":"137","author":"Droz D","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950170203"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61107-0_9"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00158-1"},{"key":"e_1_2_6_40_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<446::AID-IJC23>3.0.CO;2-B","article-title":"Complex cadherin expression in human prostate cancer cells","volume":"85","author":"Bussemakers MG","year":"1994","journal-title":"Int J Cancer"},{"key":"e_1_2_6_41_2","first-page":"3650","article-title":"Cadherin\u2010switching in human prostate cancer progression","volume":"60","author":"Tomita K","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00120.x"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:53:23Z","timestamp":1700322803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,29]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1002\/ijc.10623"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10623","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,29]]}}}