{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:41:40Z","timestamp":1790959300881,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,8,16]],"date-time":"2002-08-16T00:00:00Z","timestamp":1029456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A positive family history is an increased risk factor for gastric cancer within family members, and one of the possible causes of this is the intrafamilial clustering of <jats:italic>Helicobacter pylori<\/jats:italic> infection. Our study examined the prevalence of <jats:italic>H. pylori<\/jats:italic> infection, serum antibodies to CagA and VacA and atrophic gastritis and\/or intestinal metaplasia in the offspring or siblings of gastric cancer patients. A total of 726 subjects included 300 relatives of 300 separate gastric cancer patients and 426 controls. All subjects underwent upper gastrointestinal endoscopic examination with a rapid urease test. Blood samples were obtained to test for the presence of serum antibodies to the CagA and VacA proteins of <jats:italic>H. pylori<\/jats:italic>. The prevalence of <jats:italic>H. pylori<\/jats:italic> infection was higher in relatives of cancer patients (75.3%) than in controls (60.1%), and the adjusted odds ratio was 2.1 (95% CI 1.5\u20132.9). When either siblings or 2 or more family members were gastric cancer patients, the prevalence of <jats:italic>H. pylori<\/jats:italic> infection was much higher compared to the prevalence in controls. There was no specific relationship between CagA and VacA, and <jats:italic>H. pylori<\/jats:italic> infection. Atrophic gastritis and\/or intestinal metaplasia were more frequently found in <jats:italic>H. pylori<\/jats:italic>\u2010infected relatives of cancer patients (26.1%) than in <jats:italic>H. pylori<\/jats:italic>\u2010infected controls (12.9%). These results strongly support a role for <jats:italic>H. pylori<\/jats:italic> infection in familial aggregation of gastric cancer. The prophylactic eradication of <jats:italic>H. pylori<\/jats:italic> infection in the offspring or siblings of gastric cancer patients may be clinically beneficial. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10637","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T22:57:58Z","timestamp":1034117878000},"page":"469-474","source":"Crossref","is-referenced-by-count":58,"title":["Role of <i>Helicobacter pylori<\/i> infection among offspring or siblings of gastric cancer 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