{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:29:57Z","timestamp":1768465797556,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T00:00:00Z","timestamp":1031184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Screening mammography has greatly increased the number of non\u2010palpable breast carcinomas diagnosed in asymptomatic women. Malignant\u2010appearing microcalcifications represent one of the earliest mammographic findings of non\u2010palpable breast carcinomas. Many studies have attempted to correlate radiological and histological features of malignant\u2010appearing microcalcifications. In the present study, we evaluated the association between mammographically detected malignant\u2010appearing microcalcifications and the expression profile of selected biological markers in non\u2010palpable breast carcinomas. Two hundred and eighty patients with non\u2010palpable suspicious breast lesions that were detected during screening mammography were studied. All patients underwent mammographically\u2010guided needle localization\u2010excision breast biopsy. Histological examination showed 74 (26.4%) carcinomas of various subtypes. Immunohistochemistry was carried out in 58\/74 carcinomas by using a panel of monoclonal and polyclonal antibodies against estrogen receptor (ER), progesterone receptor (PR), HER\u20102\/neu, Bcl\u20102, Bax, Fas and DNA fragmentation factor (DFF). Malignant\u2010appearing microcalcifications was the major mammographic finding in 45\/58 (77%) patients. Nuclear ER positivity (65.5%) and PR positivity (46.5%) of non\u2010palpable breast carcinomas were statistically correlated with malignant\u2010appearing microcalcifications (<jats:italic>p<\/jats:italic> &lt; 0.01 and <jats:italic>p<\/jats:italic> &lt; 0.05, respectively). Statistically significant associations were also found between malignant\u2010appearing microcalcifications and HER\u20102\/neu positivity (<jats:italic>p<\/jats:italic> &lt; 0.01), Bax positivity (<jats:italic>p<\/jats:italic> &lt; 0.01), Fas positivity (<jats:italic>p<\/jats:italic> &lt; 0.05) and DFF positivity (<jats:italic>p<\/jats:italic> &lt; 0.01), whereas no statistical correlation was found with Bcl\u20102 positivity (<jats:italic>p<\/jats:italic> &gt; 0.05). Malignant\u2010appearing microcalcifications detected during screening mammography represent a diagnostic, prognostic and therapeutic challenge. The mammographic\/biological associations and their potential implications in the management of women with non\u2010palpable breast carcinomas are thoroughly discussed. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10654","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:28:15Z","timestamp":1034137695000},"page":"86-90","source":"Crossref","is-referenced-by-count":43,"title":["Non\u2010palpable breast carcinomas: Correlation of mammographically detected malignant\u2010appearing microcalcifications and molecular prognostic factors"],"prefix":"10.1002","volume":"102","author":[{"given":"Michalis 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