{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:23:08Z","timestamp":1791397388227,"version":"4.3.3"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,10,24]],"date-time":"2002-10-24T00:00:00Z","timestamp":1035417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004084","name":"Korea Science and Engineering Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004084","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Angioimmunoblastic T cell lymphoma (AILT) is a rare lymphoma that is regarded as a clinicopathologic entity but shows considerable histomorphologic diversity, variable immunophenotypes and inconsistent T cell receptor (TCR) gene rearrangement. One hundred four paraffin blocks of AILT were investigated defining tumor cell lineage by triple immunostains with a confocal laser scanning microscope and correlating morphology, immunophenotype and TCR\u03b3 gene rearrangement to clinical outcome. Ninety\u2010nine cases were CD4\n                    <jats:sup>+<\/jats:sup>\n                    , some of them showing a mixture of CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    tumor cells. The remaining 5 specimens were CD3\n                    <jats:sup>+<\/jats:sup>\n                    \/CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/CD8\n                    <jats:sup>\u2212<\/jats:sup>\n                    . A considerable number of T cells of different subtypes could always be found, but even in 13 cases predominated by CD8\n                    <jats:sup>+<\/jats:sup>\n                    cells, proliferation could be attributed to atypical CD4\n                    <jats:sup>+<\/jats:sup>\n                    cells. TCR\u03b3 gene rearrangement was monoclonal in 48 cases (69%) among 70 tested. In 29 of these semi\u2010quantitative gene scan analysis resulted in a median proportion of monoclonal peak of 35% of PCR\u2010products. Clinical outcome was identical grouping patients by clonality of TCR\u03b3, absence or presence of clear cell clusters and international prognostic index. We conclude that AILT is mainly derived from CD2\n                    <jats:sup>+<\/jats:sup>\n                    CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD5\n                    <jats:sup>+<\/jats:sup>\n                    CD7\n                    <jats:sup>\u2212<\/jats:sup>\n                    mature T\u2010helper cells with varying expression and partial loss of detectable CD4. A significant number of non\u2010neoplastic T cells (resting CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and activated small or medium\u2010sized CD8\n                    <jats:sup>+<\/jats:sup>\n                    lymphocytes) may coexist with a minor neoplastic T cell population. Clinicopathologic correlation suggests AILT to be a well defined homogeneous entity with poor prognosis. Currently no prognostic factors can be derived. \u00a9 2002 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.10758","type":"journal-article","created":{"date-parts":[[2002,12,19]],"date-time":"2002-12-19T08:59:09Z","timestamp":1040288349000},"page":"12-20","source":"Crossref","is-referenced-by-count":64,"title":["Angioimmunoblastic T cell lymphoma is derived from mature T\u2010helper cells with varying expression and loss of detectable CD4"],"prefix":"10.1002","volume":"103","author":[{"given":"Seung\u2010Sook","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"R\u00fcdiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Odenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Starostik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Konrad","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11,26]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1246","article-title":"Zur Natur, Prognose und Nomenklatur der angioimmunoblastischen Lymphadenopathie (Lymphogranulomatosis X bzw. T\u2010Zonen\u2010Lymphom)","volume":"104","author":"Lennert K","year":"1979","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501022920101"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90553-4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90466-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81246-0_28"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197802)41:2<578::AID-CNCR2820410226>3.0.CO;2-8"},{"key":"e_1_2_5_8_2","first-page":"127","article-title":"Zytogenetische Befunde bei Morbus Hodgkin, Lymphogranulomatosis X und T\u2010Zonen\u2010Lymphom","volume":"66","author":"Schwarze EW","year":"1982","journal-title":"Verh Dtsch Ges Pathol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood.V60.4.877.877","article-title":"Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy","volume":"60","author":"Kaneko Y","year":"1982","journal-title":"Blood"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(87)90024-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370408"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.11.1229"},{"key":"e_1_2_5_13_2","first-page":"392","article-title":"Clonal T cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy\u2010like lymphoma","volume":"122","author":"Weiss LM","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1182\/blood.V72.3.1000.bloodjournal7231000","article-title":"Clinicopathologic, immunophenotypic and immunogenotypic analyses of immunoblastic lymphadenopathy\u2010like T cell lymphoma","volume":"72","author":"Tobinai K","year":"1988","journal-title":"Blood"},{"key":"e_1_2_5_15_2","first-page":"712","article-title":"Clonal T cell population in angioimmunoblastic lymphadenopathy and related lesions","volume":"78","author":"Suzuki H","year":"1987","journal-title":"Jpn J Cancer Res"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112860"},{"key":"e_1_2_5_17_2","first-page":"549","article-title":"Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy","volume":"133","author":"Feller AC","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90367-4"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_5_20_2","volume-title":"World Health Organization classification of tumours. Pathology and genetics of tumours of hematopoietic and lymphoid tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199806000-00001"},{"key":"e_1_2_5_22_2","first-page":"821","article-title":"The rapid detection of clonal T cell proliferations in patients with lymphoid disorders","volume":"138","author":"McCarthy KP","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF00195772","article-title":"Angioimmunoblastic lymphadenopathy type of T cell lymphoma and angioimmunoblastic lymphadenopathy: a clinicopathological and molecular biological study of 13 Chinese patients using polymerase chain reaction and paraffin\u2010embedded tissues","volume":"424","author":"Lorenzen J","year":"1994","journal-title":"Virchows Arch"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910515)67:10<2565::AID-CNCR2820671029>3.0.CO;2-4"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920515)69:10<2571::AID-CNCR2820691030>3.0.CO;2-S"},{"key":"e_1_2_5_26_2","first-page":"1","article-title":"Angioimmunoblastic lymphadenopathy and related disorders: a retrospective look in search of definitions","volume":"3","author":"Frizzera G","year":"1989","journal-title":"Leukemia"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861115)58:10<2224::AID-CNCR2820581011>3.0.CO;2-3"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193945"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890415)63:8<1625::AID-CNCR2820630832>3.0.CO;2-J"},{"key":"e_1_2_5_30_2","series-title":"Major problems in pathology","first-page":"391","author":"Jaffe ES","year":"1995"},{"key":"e_1_2_5_31_2","first-page":"1093","article-title":"Epstein\u2010Barr virus in a CD8\u2010positive T cell lymphoma","volume":"136","author":"Richel DJ","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_5_32_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/blood.V72.2.413.413","article-title":"Characteristic karyotypic pattern in T cell lymphoproliferative disorders with reactive \u201cangioimmunoblastic lymphadenopathy with dysproteinemia\u2010type\u201d features","volume":"72","author":"Kaneko Y","year":"1988","journal-title":"Blood"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02290.x"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90148-X"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<432::AID-PATH942>3.0.CO;2-4"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.50.1.15"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.2.152"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06937.x"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(96)00021-1"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb01326.x"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97187-7"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01973602"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00491.x"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199810000-00003"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.1.192.192"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.5.1165.1165"},{"key":"e_1_2_5_48_2","first-page":"279","article-title":"Phenotyping of proliferating lymphocytes in angioimmunoblastic lymphadenopathy and related lesions by the double immunoenzymatic staining technique","volume":"127","author":"Namikawa R","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820690531"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.131.1.212"},{"key":"e_1_2_5_51_2","first-page":"177","article-title":"Peripheral T cell and NK\u2010cell neoplasms: an integrated approach to diagnosis","volume":"12","author":"Chan JK","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_5_52_2","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1093\/annonc\/9.suppl_5.S31","article-title":"Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma)","volume":"9","author":"R\u00fcdiger T","year":"1998","journal-title":"Ann Oncol"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1994.1354"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64141-7"},{"key":"e_1_2_5_55_2","first-page":"316","article-title":"Morphologic and immunologic characterization of 50 peripheral T cell lymphomas","volume":"118","author":"Weiss LM","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_5_56_2","first-page":"181","article-title":"Immunophenotypic criteria for the diagnosis of non\u2010Hodgkin's lymphoma","volume":"128","author":"Picker LJ","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_5_57_2","first-page":"151","article-title":"Angio\u2010immunoblastic lymphadenopathy: report of ten cases and review of the literature","volume":"48","author":"Cullen MH","year":"1979","journal-title":"Q J Med"},{"key":"e_1_2_5_58_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2296"},{"key":"e_1_2_5_59_2","first-page":"76","article-title":"Prognostic significance of T cell phenotype in aggressive non\u2010Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA)","volume":"92","author":"Gisselbrecht C","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf033"},{"key":"e_1_2_5_61_2","volume-title":"Ackerman's surgical pathology","author":"Rosai J","year":"1996"},{"key":"e_1_2_5_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.9.995"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10758","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:46:32Z","timestamp":1697204792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,26]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/ijc.10758"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10758","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,26]]}}}