{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:39:52Z","timestamp":1791164392046,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,1,3]],"date-time":"2003-01-03T00:00:00Z","timestamp":1041552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Incessant ovulation is thought to be one of the primary causes of epithelial ovarian cancer. However, the effects of ovulation at different ages and of the various exposures or events that suppress ovulation have not been established. We used data from an Australian case\u2010control study of 791 ovarian cancer cases and 853 controls to examine the effect of ovulation on ovarian cancer risk. The total number of lifetime ovulations was calculated using information provided in a monthly contraceptive\/reproductive calendar, as well as incorporating other information such as average menstrual cycle length. An increase of 1 year's worth of ovulation was associated with a 6% increase in risk of ovarian cancer (95% confidence interval [CI] = 4\u20138%). Ovulations in the 20\u201329\u2010year age group were associated with the greatest risk, with a 20% increase in risk associated with each year of ovulation during this age period (95% CI = 13\u201326%). When the effects of different exposures that suppress ovulation were compared, there was an indication that some factors may have a greater effect than others. These findings support the theory that incessant ovulation is a major contributor to the occurrence of ovarian cancer and suggest that ovulations during the 20s may be those most associated with disease risk. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10927","type":"journal-article","created":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T01:48:03Z","timestamp":1044496083000},"page":"228-232","source":"Crossref","is-referenced-by-count":136,"title":["Ovulation and risk of epithelial ovarian cancer"],"prefix":"10.1002","volume":"104","author":[{"given":"David M.","family":"Purdie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Siskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le C.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92335-X"},{"key":"e_1_2_6_3_2","first-page":"21","article-title":"Epidemiologic evidence for the increased cell proliferation model of carcinogenesis","volume":"369","author":"Preston Martin S","year":"1991","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-0272(92)90047-R"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116429"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/21.1.23"},{"key":"e_1_2_6_7_2","first-page":"3670","article-title":"Population\u2010based case\u2010control study of ovarian cancer in Shanghai","volume":"49","author":"Shu XO","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115030"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115076"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/12.2.161"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113523"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113207"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91435-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910620606"},{"key":"e_1_2_6_15_2","first-page":"645","article-title":"Incidence of ovulation from the menarche to the menopause: observations of 622 New Zealand women","volume":"96","author":"Metcalf MG","year":"1983","journal-title":"N Z Med J"},{"key":"e_1_2_6_16_2","volume-title":"Registration of Births, Deaths and Marriages Act","author":"Australian Government","year":"1996"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54180-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/oso\/9780198283713.003.0024","volume-title":"Biomedical and demographic determinants of reproduction","author":"McNeilly AS","year":"1993"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.9.860"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020678100977"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9681(87)80009-7"},{"key":"e_1_2_6_22_2","first-page":"1253","article-title":"Adeno\u2010carcinomata in hens kept in a constant environment","volume":"37","author":"Wilson JE","year":"1958","journal-title":"Poult Sci"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00061-8"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113189"},{"key":"e_1_2_6_25_2","series-title":"Cancer incidence in five continents","author":"Parkin DM","year":"1992"},{"key":"e_1_2_6_26_2","first-page":"47","article-title":"Malignant and benign ovarian neoplasms among atomic bomb survivors, Hiroshima and Nagasaki, 1950\u201380","volume":"79","author":"Tokuoka S","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200003000-00005"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(98)00017-3"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.1.32"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.3.217"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.13.932"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.22.1729"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.17.1459"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10927","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:19:28Z","timestamp":1700248768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,3,20]]}},"alternative-id":["10.1002\/ijc.10927"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10927","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2,4]]}}}