{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:04:00Z","timestamp":1791338640664,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,1,24]],"date-time":"2003-01-24T00:00:00Z","timestamp":1043366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Src homology 2 domain protein 1A (SH2D1A) is a small, 128\u2010amino acid protein consisting of a single SH2 domain; it is probably involved in signal regulation. It is expressed in activated T and natural killer (NK) cells, but not in B lymphocytes. It was discovered in studies on the rare hereditary condition X\u2010linked lymphoproliferative disease (XLP). Individuals with this condition either lack or carry an altered protein. The serious symptoms (fatal mononucleosis) present almost exclusively at the first encounter with Epstein\u2010Barr virus (EBV). The absence of SH2D1A in B cells, which are the targets of EBV, has to be reconciled with this clinical situation. In an earlier search for B lymphocytes expressing SH2D1A, we detected it in EBV\u2010carrying type I Burkitt's lymphoma (BL) lines. We now show SH2D1A in 5 EBV\u2010negative classical Hodgkin's disease (HD)\u2010derived cell lines. Two lines belong to the T lineage and 3 to the B lineage. One B\u2010HD line, which originated from nodular lymphocyte\u2010predominant Hodgkin's lymphoma and differed in phenotype, was SH2D1A\u2010negative. This finding is in accordance with the previously reported abundant SH2D1A mRNA in Hodgkin and Reed\u2010Sternberg (HRS) cells. We thus found SH2D1A expression in lines of malignant origin assigned to the B lineage. Its presence in HRS cells may lead us closer to an understanding of the pathophysiology of the serious syndrome connected with EBV infection in XLP patients, because HRS\u2010like cells have been detected in the lymphoid tissue of patients with infectious mononucleosis. It is likely therefore that in addition to the demonstrated functional defect of T and NK cells imposed by the SH2D1A mutation, the behavior of certain EBV\u2010infected B lymphocytes is also modified. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10986","type":"journal-article","created":{"date-parts":[[2003,2,20]],"date-time":"2003-02-20T14:04:54Z","timestamp":1045749894000},"page":"658-661","source":"Crossref","is-referenced-by-count":20,"title":["Expression of SH2D1A in five classical Hodgkin's disease\u2010derived cell lines"],"prefix":"10.1002","volume":"104","author":[{"given":"Lor\u00e1nd 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