{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:27:57Z","timestamp":1775060877409,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,1,24]],"date-time":"2003-01-24T00:00:00Z","timestamp":1043366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association of cytokine genotypes with gastric carcinoma (GC) may be influenced by environmental factors and varies among different populations. Few studies have addressed the impact of different cytokine genotypes on the development and progression of GC. We analyzed 11 functional polymorphisms in tumor necrosis factor\u2010\u03b1 (<jats:italic>TNF<\/jats:italic>\u2010\u03b1), interleukin (<jats:italic>IL<\/jats:italic>)\u20101, <jats:italic>IL\u20104<\/jats:italic> and <jats:italic>IL\u201010<\/jats:italic> genes in 220 Taiwanese Chinese with GC and in 230 healthy controls. The risk of genotypes was adjusted with confounding environmental risks. Our results revealed that the frequency of <jats:italic>Helicobacter pylori<\/jats:italic> infection [odds ratio (OR) 1.7, 95% confidence interval (CI) 1.19\u20132.56], cigarette smoking (OR 2.02, 95% CI 1.38\u20132.95) and high <jats:italic>IL\u201010<\/jats:italic> producer genotype (OR 2.67, 95% CI 1.29\u20135.50) was significantly increased in the entire GC patients. Among different subtypes of GC, a higher risk of developing diffuse type (OR 1.64, 95% CI 1.01\u20132.67) or cardia cancer (OR 2.44, 95% CI 1.13\u20132.67) was observed for the CT\/CC genotype of <jats:italic>IL\u20104<\/jats:italic> at the position \u2212590, whereas the high <jats:italic>IL\u201010<\/jats:italic> producer genotype was significantly linked with the risk of cardia cancer (OR 3.21, 95% CI 1.06\u20139.73) or advanced stage (OR 2.29, 95% CI 1.12\u20134.64). No association was noted between GC and controls in the distribution of <jats:italic>IL\u20101<\/jats:italic> and <jats:italic>TNF<\/jats:italic>\u2010\u03b1 genotypes. Logistic regression analyses revealed that <jats:italic>H. pylori<\/jats:italic> infection (OR 1.7, 95% CI 1.14\u20132.52), cigarette smoking (OR 1.87, 95% CI 1.27\u2013\u20102.96) and <jats:italic>IL\u201010<\/jats:italic> genotype (OR 2.54, 95% CI 1.24\u20135.61) are independent risks for GC. Independent effects of <jats:italic>IL\u201010<\/jats:italic> genotype, <jats:italic>H. pylori<\/jats:italic> infection and cigarette smoking indicate that carcinogenesis of GC is influenced by a variety of host and environmental factors. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10987","type":"journal-article","created":{"date-parts":[[2003,2,20]],"date-time":"2003-02-20T14:04:54Z","timestamp":1045749894000},"page":"617-623","source":"Crossref","is-referenced-by-count":163,"title":["Interleukin\u201010 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese"],"prefix":"10.1002","volume":"104","author":[{"given":"Ming\u2010Shiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Tsan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Tung","family":"Shun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaw\u2010Town","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507063330107"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10466"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9116"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-12-199406150-00002"},{"key":"e_1_2_5_6_2","first-page":"2684","article-title":"Gastric 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