{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:57:45Z","timestamp":1788785865351,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,2,13]],"date-time":"2003-02-13T00:00:00Z","timestamp":1045094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Routine pathological examination cannot distinctively predict the clinical course of meningiomas because even histologically benign tumors may recur after gross total resection. Numerous efforts have been made for the evaluation of different immunohistochemical assays in meningioma prognosis. We investigated the prognostic significance of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression by immunohistochemical analysis of 271 meningiomas. All tumors were additionally stained for the proliferation markers Ki\u201067 and DNA topoisomerase II alpha (TopoII\u03b1). Significant differences between the number of p16INK4a\u2010, p18INK4c\u2010 and p21CIP1\u2010positive cases were noted among the 3 grades of meningiomas. p16INK4a\u2010 and p21CIP\u2010positive tumors were found to prevail among benign meningiomas, whereas p18INK4c immunostaining was closely associated to anaplastic meningiomas. The number of p16INK4a\u2010 and p21CIP\u2010positive cases was significantly lower in the cohort of recurrent meningiomas. In contrast, p18INK4c\u2010positive cases were clustered among recurrent meningiomas regardless of tumor grade. Immunoreactivity of p14ARF, p27KIP1 and p73 did not show any differences between meningiomas of various histology and clinical outcomes. Multivariate analysis revealed that only tumor grade and TopoII\u03b1 index are independent criteria for predicting meningioma recurrence. Thus, the immunohistochemical assessment of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in meningiomas does not appear to provide prognostically useful information. Further studies are needed to identify more reliable prognostic markers and to address in more detail the role of cell cycle aberrations in these tumors. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11013","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T18:46:17Z","timestamp":1047494777000},"page":"728-734","source":"Crossref","is-referenced-by-count":52,"title":["Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome"],"prefix":"10.1002","volume":"104","author":[{"given":"Andrey","family":"Korshunov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Shishkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Golanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"67","volume-title":"Russel and Rubinstein pathology of tumors of the nervous system","author":"Bruner JM","year":"1998"},{"key":"e_1_2_6_3_2","first-page":"176","volume-title":"Tumours of the nervous system; pathology and genetics: WHO International classification of tumours","author":"Louis DN","year":"2000"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.27119"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1998.00150.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90224-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01229.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80050-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1997.tb01327.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050266"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2249::AID-CNCR21>3.0.CO;2-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00006"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2262::AID-CNCR23>3.0.CO;2-R"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5858\/1999-123-0793-HFAMLI","article-title":"Histopathological features and MIB\u20101 labeling indices in recurrent and non\u2010recurrent meningiomas","volume":"123","author":"Abramovich CM","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005794700267"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.10.872"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1309\/ULMT-V1UC-D69H-MMQF"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0305-1846.2001.00300.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006440430585"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005946001915"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000826"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.5858\/2002-126-1079-DTIACA","article-title":"DNA topoisomerase II \u03b1 and cyclin A immuno expression in meningiomas and its prognostic significance. 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