{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:39:52Z","timestamp":1790779192647,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,5]],"date-time":"2003-03-05T00:00:00Z","timestamp":1046822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"New Jersey Commission for Cancer Research","award":["01-1079-CCR-N-0"],"award-info":[{"award-number":["01-1079-CCR-N-0"]}]},{"name":"New Jersey Commission for Cancer Research","award":["NJCRR 02\/03-1105-CMM-NO"],"award-info":[{"award-number":["NJCRR 02\/03-1105-CMM-NO"]}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["R01 CA60764"],"award-info":[{"award-number":["R01 CA60764"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cells in human tumor xenografts express similar levels of angiogenic growth factors before treatment. After radioimmunotherapy (RAIT) surviving tumor cells upregulate angiogenic growth factors, including placenta growth factor (PlGF), in a tumor\u2010specific pattern. To determine the role of post\u2010treatment PlGF expression on blood vessel recovery, tumor xenografts were assayed for post\u2010RAIT vessel density (CD34+), proliferation (PCNA+) and maturity (SMA+ pericytes\/mural cells). To further analyze the role of PlGF in blood vessel formation, PlGF\u2010containing Matrigel implants were also assessed in a similar manner. The xenografts producing post\u2010treatment PlGF increased CD34+ microvessel density 2\u2010 to 4\u2010fold over untreated controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) within 3 weeks of RAIT treatment. The proportion of mature microvessels (SMA+) decreased. Pericyte coverage and density of microvessels remained stable in the tumor that expressed neither PlGF nor VEGF after treatment. Hemoglobin content of PlGF\u2010containing Matrigel implants was 5.7\u2010fold that of anti\u2010PlGF\/anti\u2010VEGF treated controls (Day 6,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.03). The vessel density in PlGF\u2010implants averaged 36.8 \u00b1 10.6\/mm compared to 4.9 \u00b1 6.5\/mm\n                    <jats:sup>2<\/jats:sup>\n                    in controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Vessels of PlGF\u2010implants were lined by vWF+ cells, which were mostly flt\u20101+. These findings point to a role for PlGF in rapid restoration of tumor blood supply after treatment and thus, to enhanced likelihood of tumor regrowth. Likewise, the cells of primary human tumors that upregulate PlGF after treatment may be more likely to survive and form recurring tumors. Prevention of this angiogenic response to treatment may require administration of anti\u2010angiogenic therapy during, rather than after, treatment. \u00a9 2003 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.11059","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T12:37:48Z","timestamp":1049287068000},"page":"158-164","source":"Crossref","is-referenced-by-count":56,"title":["Altered tumor vessel maturation and proliferation in placenta growth factor\u2010producing tumors: Potential relationship to post\u2010therapy tumor angiogenesis and recurrence"],"prefix":"10.1002","volume":"105","author":[{"given":"Alice 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