{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:56:02Z","timestamp":1773291362792,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,5]],"date-time":"2003-03-05T00:00:00Z","timestamp":1046822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to investigate the association of <jats:italic>cyclin D1<\/jats:italic> (G870A) single nucleotide polymorphism with susceptibility to esophageal and cardiac carcinoma in a northern Chinese population. By polymerase chain reaction\u2010single strand conformation polymorphism analysis, <jats:italic>cyclin D1<\/jats:italic> (G870A) genotyping was carried out among 120 patients with esophageal squamous cell carcinoma (ESCC), 87 patients with gastric cardiac adenocarcinoma (CAC), and 183 age\u2010 and gender\u2010matched controls. The <jats:italic>cyclin D1<\/jats:italic> genotype distribution among ESCC patients was significantly different from that among healthy controls (\u03c7<jats:sup>2<\/jats:sup> = 7.372, <jats:italic>p<\/jats:italic> = 0.025). The G\/G genotype was significantly less frequent among ESCC patients (9.2%) than among healthy controls (20.8%) (\u03c7<jats:sup>2<\/jats:sup> = 7.192, <jats:italic>p<\/jats:italic> = 0.007). The G\/G genotype significantly reduced risk for the development of ESCC compared to the combination of G\/A and A\/A genotypes (adjusted odds ratio [OR] = 0.37, 95% confidence interval [CI] = 0.16\u20130.83). After stratification according to smoking status, the A\/A frequency among smoking ESCC (34.3%) and CAC patients (35.7%) was significantly higher than that among smoking healthy controls (18.6%) (\u03c7<jats:sup>2<\/jats:sup> = 5.426 and 5.599, <jats:italic>p<\/jats:italic> = 0.020 and 0.018, respectively). Smokers with the A\/A genotype had an about 2\u2010fold increased risk for both of ESCC and CAC compared to the G\/A and G\/G genotypes, with an adjusted OR of 2.26 in ESCC (95% CI = 1.14\u20134.49) and of 2.42 in CAC (95% CI = 1.17\u20134.98). No correlation between the <jats:italic>cyclin D1<\/jats:italic> genotype and development of ESCC or CAC was found among nonsmokers. Determination of the <jats:italic>cyclin D1<\/jats:italic> (G870A) single nucleotide polymorphism may be suitable to identify individuals with increased risk for ESCC or CAC in the northern Chinese population. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11067","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T17:37:48Z","timestamp":1049305068000},"page":"281-284","source":"Crossref","is-referenced-by-count":53,"title":["Association of <i>cyclin D1<\/i> (G870A) polymorphism with susceptibility to esophageal and gastric cardiac carcinoma in a northern Chinese population"],"prefix":"10.1002","volume":"105","author":[{"given":"Jianhui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denggui","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Sarbia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,3,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.338S"},{"key":"e_1_2_6_3_2","first-page":"225","article-title":"Factors 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