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In view of these observations, we have undertaken a comprehensive survey of the cadherin subtypes present in normal ovarian surface epithelium and peritoneum and in the tumors and peritoneal effusions of women diagnosed with Stage I or Stage II primary ovarian cancer using a degenerate cloning strategy for sequences highly conserved among this family of cell adhesion molecules. On the basis of the nucleotide sequences of the resultant PCR products, multiple cadherin subtypes (E\u2010, N\u2010, P\u2010cadherin, and cadherin\u20104, \u20106, and \u201011) were found to be present in these normal and malignant tissues and cells. P\u2010cadherin was determined to be the predominant cadherin subtype in normal peritoneum, peritoneal effusions and Stage II tumor masses. An increase in P\u2010cadherin mRNA and protein expression levels in ovarian tumor masses with progression to later stages of the disease state was confirmed by Northern and Western blot analysis, respectively. In addition, we have determined that the cadherin\u2010associated protein, known as \u03b2\u2010catenin, is expressed in normal peritoneum, ovarian tumors and malignant cell effusions obtained from women with Stage I or Stage II cancer. Immunoprecipitation studies demonstrated that P\u2010cadherin was capable of interacting with \u03b2\u2010catenin in these normal and malignant tissues and cells. Collectively, these findings suggest that the regulated expression of P\u2010cadherin\/\u03b2\u2010catenin complexes in ovarian tumor cells may represent a key step in disease progression. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11086","type":"journal-article","created":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T10:07:37Z","timestamp":1054894057000},"page":"172-177","source":"Crossref","is-referenced-by-count":104,"title":["Cadherin switching in ovarian cancer progression"],"prefix":"10.1002","volume":"106","author":[{"given":"Ila S.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavneesh","family":"Madan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiro","family":"Getsios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique 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