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Allelotyping and telomerase analysis were carried out on 28 high\u2010grade cervical lesions (CIN III: <jats:italic>n<\/jats:italic> = 20; cervical carcinomas: <jats:italic>n<\/jats:italic> = 8), using 23 microsatellite markers on 3p, 6p and 6q. Clear telomerase activity was found in 17 of 28 lesions (61%). Allelic imbalance frequency at 6q14\u201322 was significantly higher in lesions with detectable telomerase activity, compared to lesions without telomerase activity (<jats:italic>p<\/jats:italic> = 0.02). No association was found between telomerase activity and AI at any of the remaining regions studied on 3p and chromosome 6. In addition, in telomerase positive passages of the HPV 16 immortalized cell line FK16A, shown recently to be responsive to chromosome 6 mediated telomerase repression, AI was found in the overlapping region of 6q14\u201327. These data suggest that 6q14\u201322 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11145","type":"journal-article","created":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T20:01:39Z","timestamp":1052164899000},"page":"577-582","source":"Crossref","is-referenced-by-count":12,"title":["Telomerase activity in high\u2010grade cervical lesions is associated with allelic imbalance at 6Q14\u201322"],"prefix":"10.1002","volume":"105","author":[{"given":"Mark","family":"van Duin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renske D.M.","family":"Steenbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian","family":"de Wilde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo 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