{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:17:14Z","timestamp":1780589834948,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T00:00:00Z","timestamp":1058918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infectious mononucleosis (IM) is an established risk factor for Hodgkin's disease (HD). A substantial minority (33%) of cases of HD have Epstein\u2010Barr virus (EBV) DNA within the malignant cells (are EBV<jats:sup>+ve<\/jats:sup>). It is unclear whether risk after IM applies specifically to EBV<jats:sup>+ve<\/jats:sup> HD. We report the results of a population\u2010based case\u2010control study of HD in adults (<jats:italic>n<\/jats:italic> = 408 cases of classical HD, 513 controls) aged 16\u201374 years; the case series included 113 EBV<jats:sup>+ve<\/jats:sup> and 243 EBV<jats:sup>\u2010ve<\/jats:sup> HD. Analyses compared total HD, EBV<jats:sup>+ve<\/jats:sup> HD and EBV<jats:sup>\u2010ve<\/jats:sup> HD with the controls and EBV<jats:sup>+ve<\/jats:sup> HD with EBV<jats:sup>\u2010ve<\/jats:sup> HD cases using, mainly, logistic regression. Regression analyses were adjusted for gender, age\u2010group and socioeconomic status, and were performed for the whole age range and separately for young (&lt; 35 years) and old adults (\u2265 35 years); formal tests of effect modification by age were included. For the young adults, reported IM in index or relative was strongly and significantly associated with EBV<jats:sup>+ve<\/jats:sup> HD when compared to controls (odds ratio [OR] = 2.94, 95% confidence interval [CI]: 1.08\u20137.98 and OR = 5.22, 95% CI: 2.15\u201312.68, respectively). These results may be interpreted as indications that late first exposure to EBV increases risk of HD, especially in young adults; this applies primarily to EBV<jats:sup>+ve<\/jats:sup> HD. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11156","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T13:41:56Z","timestamp":1061991716000},"page":"298-302","source":"Crossref","is-referenced-by-count":44,"title":["An epidemiologic study of index and family infectious mononucleosis and adult Hodgkin's disease (HD): Evidence for a specific association with EBV<sup>+ve<\/sup> HD in young adults"],"prefix":"10.1002","volume":"107","author":[{"given":"Freda E.","family":"Alexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davia J.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Freeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Krajewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Angus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Malcolm","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth F.","family":"Jarrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1189","article-title":"Epidemiology of Hodgkin's disease","volume":"26","author":"MacMahon M","year":"1966","journal-title":"Cancer Res"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101153040302"},{"key":"e_1_2_5_4_2","first-page":"92","article-title":"Epidemiology of Hodgkin's disease","volume":"7","author":"Gutensohn N","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.18.1522"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90943-J"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/7.suppl_4.S5"},{"key":"e_1_2_5_8_2","first-page":"1","article-title":"Proceedings of the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Epstein\u2010Barr virus and Kaposi's sarcoma herpesvirus\/human herpesvirus 8. Lyon, France, 17\u201324 June 1997","volume":"70","author":"IARC","year":"1997","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401097"},{"key":"e_1_2_5_10_2","first-page":"1117","article-title":"Correlation between EBV\u2010status and risk factor profile in Hodgkin's disease","volume":"7","author":"Sleckman BG","year":"1998","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1049"},{"key":"e_1_2_5_12_2","first-page":"705","article-title":"Epstein\u2010Barr virus and HLA\u2010DPB1\u2010*0301 in young adult Hodgkin's disease: evidence for inherited susceptibility to Epstein\u2010Barr virus in cases that are EBV+ve","volume":"10","author":"Alexander FE","year":"2001","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"e_1_2_5_13_2","unstructured":"LawrenceDJ.The epidemiology of Hodgkin's disease with special reference to EBV status. PhD Thesis University of Edinburgh Edinburgh 1999."},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European\u2010American classification of lymphoid neoplasms\u2014a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris NL","year":"1994","journal-title":"Blood"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.2.147"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609054835"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6801.523-a"},{"key":"e_1_2_5_18_2","volume-title":"Statistical methods in epidemiology","author":"Clayton D","year":"1993"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600092"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/13.S1.23"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1872"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.11156","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.11156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:05:42Z","timestamp":1697486742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.11156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,23]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/ijc.11156"],"URL":"https:\/\/doi.org\/10.1002\/ijc.11156","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,23]]}}}