{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:27:41Z","timestamp":1725056861539},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,14]],"date-time":"2003-05-14T00:00:00Z","timestamp":1052870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>bcl\u20106, CD10 and CD38 are useful markers for identifying 2 molecularly and prognostically distinct profiles of diffuse large B\u2010cell lymphomas (LCLs), defined as germinal\u2010center B\u2010like and activated B\u2010like. We investigated the prognostic role of bcl\u20106, CD10 and CD38 immunoreactivity in 102 gastrectomized patients with primary gastric lymphomas (PGLs). There were 41 low\u2010grade marginal zone lymphomas of MALT\u2010type (LGML) and 61 diffuse large B\u2010cell lymphomas with (DLCLMLs; n = 31) or without (DLCLs; n = 30) an LGML component. bcl\u20106, CD10 and CD38 were significantly more commonly expressed in DLCL or DLCML as compared with LGML (50% <jats:italic>vs.<\/jats:italic> 48% <jats:italic>vs.<\/jats:italic> 17%, <jats:italic>p<\/jats:italic> = 0.0002 for bcl\u20106; 27% <jats:italic>vs.<\/jats:italic> 26% <jats:italic>vs.<\/jats:italic> 0%, <jats:italic>p<\/jats:italic> = 0.0004 for CD10; 45% <jats:italic>vs.<\/jats:italic> 48% <jats:italic>vs.<\/jats:italic> 13%, <jats:italic>p<\/jats:italic> = 0.0005 for CD38, respectively). CD10 immunoreactivity was independently associated with a better survival in diffuse LCL patients (5\u2010year overall survival: 88% \u00b1 8% <jats:italic>vs.<\/jats:italic> 66% \u00b1 7%; <jats:italic>p<\/jats:italic> = 0.04); bcl\u20106 or CD38 immunoreactivities did not disclose any prognostic implication. Age, presence of LGML component, lactic dehydrogenase serum levels and use of chemotherapy were additional independent prognostic factors. We conclude that CD10 immunoreactivity assessment could be a clear, easy\u2010to\u2010interpret and reliable prognostic factor in PGL. Accordingly, patients with CD10<jats:sup>+<\/jats:sup> gastric large B\u2010cell lymphomas may be at reduced risk and eligible for clinical trials evaluating more conservative therapeutic options. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11179","type":"journal-article","created":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T10:07:37Z","timestamp":1054894057000},"page":"288-291","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic value of bcl\u20106, CD10 and CD38 immunoreactivity in stage I\u2013II gastric lymphomas: Identification of a subset of CD10<sup>+<\/sup> large B\u2010cell lymphomas with a favorable outcome"],"prefix":"10.1002","volume":"106","author":[{"given":"Maurilio","family":"Ponzoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s 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