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Our study investigated the mechanisms of aloe\u2010emodin\u2010induced cell death in the human lung nonsmall cell carcinoma cell line H460. Aloe\u2010emodin (40 \u03bcM)\u2010induced apoptosis of H460 cells involves modulation of cAMP\u2010dependent protein kinase, protein kinase C, Bcl\u20102, caspase\u20103 and p38 protein expression. The relationship of various signals involved in cell death, such as cAMP\u2010dependent protein kinase, protein kinase C, Bcl\u20102, caspase\u20103 and p38, has been investigated in the regulation of apoptotic cell death of aloe\u2010emodin. We demonstrated that the expression of p38 is an important determinant of apoptotic death induced by aloe\u2010emodin. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11185","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T10:07:59Z","timestamp":1054721279000},"page":"26-33","source":"Crossref","is-referenced-by-count":40,"title":["Signaling pathway for aloe\u2010emodin\u2010induced apoptosis in human H460 lung nonsmall carcinoma cell"],"prefix":"10.1002","volume":"106","author":[{"given":"Feng\u2010Tsgh","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hsiung","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Zin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00827-4"},{"key":"e_1_2_5_3_2","first-page":"223","article-title":"Tumor inhibitors. 114. Aloe\u2010emodin: antileukemic principle isolated from Rhamnus frangula L","volume":"39","author":"Kupchan SM","year":"1976","journal-title":"Lloydia"},{"key":"e_1_2_5_4_2","first-page":"2800","article-title":"Aloe\u2010emodin is a new type of anticancer agent with selective activity against neuroectodermal tumor","volume":"60","author":"Pecere T","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704342"},{"key":"e_1_2_5_6_2","first-page":"5542","article-title":"Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl\u20102","volume":"59","author":"Nomura M","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80501-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80095-7"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81005-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.8.5053"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2000.d01-10.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0266"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.4049\/jimmunol.162.6.3395","article-title":"Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide\u2010induced apoptosis: involvement of c\u2010jun N\u2010terminal kinase\/stress\u2010activated protein kinase, p38 kinase and CPP\u201032 protease pathways","volume":"162","author":"Jun CD","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200000001-00004"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1480"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9612"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02219-0"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90401-8"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.11.2135"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7420"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00176-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(96)04345-5"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01203-X"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/08923970009016421"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.5.C1665"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008589200"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1317"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006990231186"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260001"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.11.1551"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110139"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5147"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101801200"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.11185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.11185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:44:00Z","timestamp":1697215440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.11185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,8,10]]}},"alternative-id":["10.1002\/ijc.11185"],"URL":"https:\/\/doi.org\/10.1002\/ijc.11185","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,2]]}}}