{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:56:44Z","timestamp":1761487004239},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,5,16]],"date-time":"2003-05-16T00:00:00Z","timestamp":1053043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The lymphomagenic action of <jats:italic>myc<\/jats:italic> genes in conjunction with Epstein\u2010Barr virus nuclear antigen\u20101 (EBNA\u20101) have been examined using transgenic mice in several separate tests. Synergy between Myc and EBNA\u20101 in lymphomagenesis was revealed in a cross breed study where co\u2010expression of transgenic <jats:italic>myc<\/jats:italic> and EBNA\u20101 led to a tumor latency period reduced significantly in some crosses. In the resulting bitransgenic tumors, expression of the E\u03bc\u2010<jats:italic>myc<\/jats:italic> genes was not affected by EBNA\u20101 expression. MoMLV was utilized as a transposon tag to activate cellular oncogenes by infection of E\u03bcEBNA\u20101 mice. Rearrangement at the <jats:italic>c\u2010myc<\/jats:italic> locus in B cell tumors from these mice again suggests a cooperative action between <jats:italic>myc<\/jats:italic> and EBNA\u20101. Tumors arising in E\u03bcEBNA\u20101 mice typically showed a trisomy of chromosome 15, upon which the <jats:italic>c\u2010myc<\/jats:italic> locus resides. Bitransgenic tumors (EBNA\u20101\/c\u2010myc) did not show trisomy 15. This raises the possibility that amplification of <jats:italic>c\u2010myc<\/jats:italic> is factorial in the selection of trisomy 15 in these tumors. These data indicate that <jats:italic>myc<\/jats:italic> and EBNA\u20101 act cooperatively and are not redundant in lymphomagenesis. Expression of EBNA\u20101 by EBV may provide a selection pressure in addition to translocation of the <jats:italic>c\u2010myc<\/jats:italic> locus in the genesis of endemic Burkitt's lymphoma (BL). \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11224","type":"journal-article","created":{"date-parts":[[2003,7,2]],"date-time":"2003-07-02T10:03:46Z","timestamp":1057140226000},"page":"388-395","source":"Crossref","is-referenced-by-count":28,"title":["Epstein\u2010Barr virus nuclear antigen\u20101 and Myc cooperate in lymphomagenesis"],"prefix":"10.1002","volume":"106","author":[{"given":"Mark 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