{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:46:46Z","timestamp":1790164006481,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,5,30]],"date-time":"2003-05-30T00:00:00Z","timestamp":1054252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity increases the risk of certain cancer types, <jats:italic>e.g.,<\/jats:italic> cancer of the endometrium, colon and gallbladder. For some other cancer forms, <jats:italic>e.g.,<\/jats:italic> prostate cancer, the association is less clear. We examined the association between body mass index (BMI) and hormone\u2010dependent tumors, utilizing a cohort of 21,884 Swedish twins born during 1886\u20131925. Information about BMI at different ages and potential confounding factors was collected prospectively. The Swedish Cancer Registry was used to identify cases of cancer in the prostate (<jats:italic>n<\/jats:italic> = 666), breast (<jats:italic>n<\/jats:italic> = 607), corpus uteri (<jats:italic>n<\/jats:italic> = 150) and ovary (<jats:italic>n<\/jats:italic> = 118) during 1969\u20131997. The material was analyzed as a traditional cohort and with co\u2010twin control analyses that allow for control of genetic influences. Obesity (BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>) at baseline was positively associated with cancer in the corpus uteri [relative risk (RR) = 3.03, 95% confidence interval (CI) 1.82\u20135.03], as was BMI at age 25, independently of BMI at baseline. Increased risk was also found for breast cancer but only in older women (\u226570 years). Overweight at age 25 was associated with decreased risk of breast cancer (RR = 0.51, 95% CI 0.33\u20130.78). No association was found for prostate cancer. We conclude that age is an important effect modifier of cancer risk associated with obesity and that obesity and overweight in young adult life may affect cancer risk also later in life. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11266","type":"journal-article","created":{"date-parts":[[2003,7,2]],"date-time":"2003-07-02T10:03:23Z","timestamp":1057140203000},"page":"594-599","source":"Crossref","is-referenced-by-count":92,"title":["Obesity and hormone\u2010dependent tumors: Cohort and co\u2010twin control studies based on the Swedish Twin Registry"],"prefix":"10.1002","volume":"106","author":[{"given":"Fredrik","family":"Jonsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy 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