{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:27:30Z","timestamp":1791066450413,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,7,16]],"date-time":"2003-07-16T00:00:00Z","timestamp":1058313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UICC"},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stockholm Cancer Society"},{"DOI":"10.13039\/501100003514","name":"Stockholm City Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003514","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to map and compare genomic imbalances in human papillomavirus (HPV)\u2010positive and \u2010negative squamous cell carcinomas of the tonsil. Twenty\u2010five primary carcinomas were analyzed by comparative genomic hybridization. Fifteen (60%) were found to be HPV\u2010positive by PCR, and the majority were HPV\u201016. There were statistically significant differences in the distribution of DNA gains and losses between the HPV\u2010positive and \u2010negative samples. Eleven of 15 HPV\u2010positive samples (73%) showed gain on chromosome 3q24\u2010qter, while only 4\/10 (40%) HPV\u2010negative samples had the same gain (<jats:italic>p<\/jats:italic> = 0.049). Furthermore, 4\/10 (40%) HPV\u2010negative samples but no HPV\u2010positive samples had gain on chromosome 7q11.2\u2010q22 (<jats:italic>p<\/jats:italic> = 0.017). As expected, and similar to previous studies, patients with an HPV\u2010positive tumor had a statistically significantly better disease\u2010specific survival than patients with an HPV\u2010negative tumor (<jats:italic>p<\/jats:italic> = 0.002). The most common changes, <jats:italic>e.g.,<\/jats:italic> gain on 3q or 8q, loss on 11q or 13 and loss on chromosome 7q in HPV\u2010negative tumors, did not have any influence on prognosis. However the number of cases in each subgroup was limited. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11371","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T13:41:56Z","timestamp":1061991716000},"page":"244-249","source":"Crossref","is-referenced-by-count":77,"title":["Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus\u2010positive and \u2010negative tumors"],"prefix":"10.1002","volume":"107","author":[{"given":"Liselotte","family":"Dahlgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Mellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Wangsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Heselmeyer\u2010Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bj\u00f6rnest\u00e5l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Munck\u2010Wikland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Dalianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00350-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1987.tb00196.x"},{"key":"e_1_2_6_4_2","first-page":"4122","article-title":"A 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