{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:43:12Z","timestamp":1769204592204,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,8,6]],"date-time":"2003-08-06T00:00:00Z","timestamp":1060128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>TDE2<\/jats:italic>, a gene with sequence similarity to the mouse testicular tumor\u2010differentially\u2010expressed (<jats:italic>Tde1<\/jats:italic>\/<jats:italic>MUSTETU<\/jats:italic>) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC). Here we characterized the <jats:italic>TDE2<\/jats:italic> gene and determined its transcript levels in a panel of lung tumors, adjacent nonmalignant lung tissues and a variety of normal human tissues. In addition, we show that TDE2 is a potential transmembrane protein with 11 putative transmembrane helices. Using real\u2010time quantitative PCR, we showed that <jats:italic>TDE2<\/jats:italic> transcript levels were higher in NSCLC compared to nonmalignant samples. In nonpulmonary normal tissues, the level of <jats:italic>TDE2<\/jats:italic> was the highest in bladder, kidney and muscle; moderate to low in stomach, liver, skin, placenta and ovary tissues; and undetectable in brain, spleen and heart. By <jats:italic>in situ<\/jats:italic> hybridization, we showed that 10 of 18 lung tumors and only 1 of 14 adjacent nonmalignant regions had high levels of <jats:italic>TDE2<\/jats:italic> transcripts. Alternatively, only 2 of 18 tumors and 8 of 14 adjacent nonmalignant bronchiole epithelium regions demonstrated negative to low levels of <jats:italic>TDE2<\/jats:italic> signals. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11391","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T13:41:56Z","timestamp":1061991716000},"page":"238-243","source":"Crossref","is-referenced-by-count":26,"title":["Identification of <i>TDE2<\/i> gene and its expression in non\u2010small cell lung 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