{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:14:15Z","timestamp":1790201655512,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T00:00:00Z","timestamp":1065484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FINEP (Financiadora de estudos e projetos)"},{"name":"PRONEX (Programa de Apoio aos N\u00facleos de Excelencia)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In developing countries, BL has a strong association with EBV infection during childhood. In South America, the data have shown an EBV association intermediate between that reported in the United States (30%) and that in equatorial Africa (95%). Early age at EBV infection and lower socioeconomic status have been related to increased EBV\u2010associated BL in developing countries. In Brazil, there are not enough data on childhood BL related to EBV infection. Our aim was to evaluate the clinicopathologic features and EBV association of 44 children with NHL from the state of Rio de Janeiro, situated in the southeast of Brazil. EBV was detected using RNA <jats:italic>in situ<\/jats:italic> hybridization in 36 biopsy specimens. DNA from fresh tumor samples and from paraffin\u2010embedded tissues of patients were analyzed by PCR, in which the first reaction included primers for an EBNA\u20102 common region while the nested reaction amplified the region discriminating between EBV types 1 and 2 in separate reactions. EBV was detected in 21 of 29 BLs (72%), and type 1 virus infected the majority of EBV\u2010positive BLs (18\/21). There was a trend for younger age in children with EBV\u2010positive BL compared to EBV\u2010negative BL (median age 4 compared to 6 years, respectively; <jats:italic>p<\/jats:italic> = 0.056). Our study confirmed that in the southeast of Brazil BL had an intermediate association with EBV. A higher rate of EBV\u2010associated BL was described in the northeast of Brazil. These differences are probably related to regional socioeconomic status. In conclusion, our study suggests that early infection with EBV in the background of a low socioeconomic condition associated with other environmental factors could contribute to BL in Brazil. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11443","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T14:58:26Z","timestamp":1068649106000},"page":"66-70","source":"Crossref","is-referenced-by-count":46,"title":["Geographic variation in Epstein\u2010Barr virus\u2013associated Burkitt's lymphoma in children from Brazil"],"prefix":"10.1002","volume":"108","author":[{"given":"Claudete Esteves","family":"Klumb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deilson Elgui","family":"De Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00eddia Maria Magalh\u00e3es","family":"De Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Kadma","family":"Carri\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"De Almeida Dobbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Pombo\u2010De\u2010Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Bacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Ciuvalschi","family":"Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/274756a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60470-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.7.1516.1516"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210108"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951001)76:7<1245::AID-CNCR2820760723>3.0.CO;2-D"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.12.5279.bloodjournal87125279"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009065832"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513819409022030"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1182\/blood.V79.12.3261.3261","article-title":"Molecular epidemiology of Burkitt's lymphoma from South America: differences in breakpoint location and Epstein\u2010Barr virus association from tumours in other world regions","volume":"79","author":"Gutierrez MI","year":"1992","journal-title":"Blood"},{"key":"e_1_2_6_11_2","first-page":"63","article-title":"Burkitt's lymphoma in Brazil: strong association with Epstein\u2010Barr virus","volume":"9","author":"Bacchi MM","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400609"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.2.186"},{"key":"e_1_2_6_15_2","first-page":"1","volume-title":"New developments in practical virology","author":"Voller A","year":"1982"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1182\/blood.V90.8.2863","article-title":"Recent advances in flow cytometry: application to the diagnosis of hematologic malignancies","volume":"90","author":"Jannings CD","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1128\/jvi.62.3.902-911.1988","article-title":"Structural analyses of EBER1 and EBER2 ribonucleoprotein particles present in Epstein\u2010Barr virus\u2013infected cells","volume":"62","author":"Glickman JN","year":"1988","journal-title":"J Virol"},{"key":"e_1_2_6_18_2","first-page":"1259","article-title":"Epstein\u2010Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study","volume":"139","author":"Weiss LM","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_19_2","first-page":"9.14","volume-title":"Molecular cloning, a laboratory manual","author":"Sambrook J","year":"1989"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200306000-00003"},{"key":"e_1_2_6_21_2","first-page":"3949","article-title":"Direct Epstein\u2010Barr virus (EBV) typing on peripheral blood mononuclear cells: no association between EBV type 2 infection or superinfection and the development of acquired immunodeficiency syndrome\u2013related non\u2010Hodgkin's lymphoma","volume":"93","author":"van Baarle D","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/339237a0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.9.2852-2857.1999"},{"key":"e_1_2_6_24_2","first-page":"171","volume-title":"The non\u2010Hodgkin's lymphoma","author":"Rabkin CS","year":"1997"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00046-9"},{"key":"e_1_2_6_26_2","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica\u2010IBGE Censo2000. (http:\/\/www.ibge.gov.br\/)"},{"key":"e_1_2_6_27_2","first-page":"285","article-title":"Epstein\u2010Barr virus and Burkitt's lymphoma","volume":"3","author":"Magrath IT","year":"1992","journal-title":"Semin Cancer Biol"},{"key":"e_1_2_6_28_2","first-page":"1147","article-title":"Antibodies to Epstein\u2010Barr virus in Burkitt's lymphoma and controls","volume":"43","author":"Henle G","year":"1969","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_29_2","first-page":"329","article-title":"Primary Epstein\u2010Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection","volume":"22","author":"Biggar RJ","year":"1978","journal-title":"Int J Cancer"},{"key":"e_1_2_6_30_2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1182\/blood.V91.4.1373","article-title":"Epstein\u2010Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue","volume":"91","author":"Tao Q","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1182\/blood.V78.11.3004.3004","article-title":"Subtypes of Epstein\u2010Barr virus in human immunodeficiency virus\u2013associated non\u2010Hodgkin's lymphoma","volume":"78","author":"Boyle MJ","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_32_2","first-page":"17","article-title":"Genotyping of Epstein\u2010Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue","volume":"148","author":"Cheng W\u2010G","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049685"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90125-8"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.11443","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.11443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:23:49Z","timestamp":1697214229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.11443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/ijc.11443"],"URL":"https:\/\/doi.org\/10.1002\/ijc.11443","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,7]]}}}