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In our study, we assessed the therapeutic effect of calponin h1 on peritoneal dissemination. F10 cells were overlaid on the cultured CN<jats:sup>+\/+<\/jats:sup> or CN<jats:sup>\u2212\/\u2212<\/jats:sup> MS cells and the effect of calponin h1 on retraction of MS cells was evaluated. Then, an adenoviral vector with the calponin h1 gene (AdGFP\u2010CN) inserted was constructed and was applied to CN<jats:sup>\u2212\/\u2212<\/jats:sup> MS cells or CN<jats:sup>\u2212\/\u2212<\/jats:sup> mouse peritoneum to investigate its suppressive effect on the peritoneal dissemination caused by F10 cells. Greater retraction and invasion of F10 cells were observed in CN<jats:sup>\u2212\/\u2212<\/jats:sup> MS than in CN<jats:sup>+\/+<\/jats:sup> cells <jats:italic>in vitro<\/jats:italic>, while down\u2010regulation of calponin h1 was observed in CN<jats:sup>+\/+<\/jats:sup> MS cells prior to the invasion of F10 cells. Infecting CN<jats:sup>\u2212\/\u2212<\/jats:sup> MS cells with AdGFP\u2010CN prevented their retraction and the invasion of F10 cells. Peritoneal dissemination was prominently suppressed in AdGFP\u2010CN\u2010infected CN<jats:sup>\u2212\/\u2212<\/jats:sup> mice, and the survival of those mice was significantly prolonged. Thus, calponin h1 functioned to protect host MS cells from the invasion of F10 cells. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11454","type":"journal-article","created":{"date-parts":[[2003,9,26]],"date-time":"2003-09-26T09:39:41Z","timestamp":1064569181000},"page":"557-563","source":"Crossref","is-referenced-by-count":11,"title":["Suppression of peritoneal dissemination through protecting mesothelial cells from retraction by cancer 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