{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:08Z","timestamp":1791235148853,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T00:00:00Z","timestamp":1063324800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2003,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative risk (RR) for these associations. The purpose of our study was to identify and summarize published reports on the relationship between risk of prostate cancer and family history, which is defined as having a father, brother, any first\u2010 or second\u2010degree relative or other relative affected with prostate cancer. A Medline and manual search from 1982 to 2000 identified 24 studies that reported RR and confidence intervals (CI) and satisfied inclusion criteria. Pooled RR estimates based upon a weighted average model were as follows: any affected family member RR = 1.93, CI 1.65\u20132.26; affected first\u2010degree relative RR = 2.22, CI 2.06\u20132.40; affected second\u2010degree relative RR = 1.88, CI 1.54\u20132.30; father with prostate cancer RR = 2.12, CI 1.82\u20132.51; and brother with prostate cancer RR = 2.87, CI 2.21\u20133.73). Statistical comparison of pooled data demonstrated that the RR is significantly higher for affected brother than for affected father (<jats:italic>p<\/jats:italic> &lt; 0.03). A sensitivity analysis demonstrated that these results are robust with respect to population bias. This meta\u2010analysis confirms that risk of prostate cancer is associated with family history of disease and improves the quantification of this risk. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11466","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T16:55:46Z","timestamp":1066236946000},"page":"797-803","source":"Crossref","is-referenced-by-count":148,"title":["Relative risk of prostate cancer for men with affected relatives: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"107","author":[{"given":"Deborah","family":"Watkins Bruner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Parlanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Dorgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Engstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196007\/08)13:4<739::AID-CNCR2820130414>3.0.CO;2-E"},{"key":"e_1_2_6_3_2","first-page":"47","article-title":"Genetic epidemiology of prostate cancer in the Utah Mormon genealogy","volume":"1","author":"Cannon L","year":"1982","journal-title":"Cancer Surv"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-6-1104"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5291.1371"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/301879"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/2477"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/302287"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/302994"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390100488"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/84808"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1021"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/342775"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng994"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91578-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/345310"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/346094"},{"key":"e_1_2_6_18_2","first-page":"F1\u201313","article-title":"Genetic epidemiology of prostate cancer","volume":"1998","author":"Narod S","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<477::AID-CNCR16>3.0.CO;2-K"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4135\/9781412984980"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90160-B"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04149-5"},{"key":"e_1_2_6_23_2","volume-title":"Methods for meta\u2010analysis in medical research","author":"Sutton AJ","year":"2000"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600315"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38074-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117495"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00200-3"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990190105"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00320-1"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00358-X"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<138::AID-CNCR23>3.0.CO;2-5"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.13.991"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170409"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00780-9"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970529)71:5<800::AID-IJC18>3.0.CO;2-B"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008876"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.2307\/1390807"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.17111.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7304.101"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67063-0"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199809000-00009"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199903000-00020"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970317)70:6<679::AID-IJC9>3.0.CO;2-S"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(00)00112-5"},{"key":"e_1_2_6_46_2","first-page":"53","article-title":"Family history and prostate cancer risk in a population\u2010based cohort of Iowa men","volume":"8","author":"Cerhan JR","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.21.1600"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0295-99"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66705-3"},{"key":"e_1_2_6_50_2","first-page":"509","article-title":"Lifestyle factors and prostate cancer risk: a case\u2010control study in Sweden","volume":"5","author":"Andersson SO","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1147>3.0.CO;2-C"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1086\/320114"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015755219674"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8890"},{"key":"e_1_2_6_55_2","first-page":"557","article-title":"Height, body weight, and risk of prostate cancer","volume":"6","author":"Giovannucci E","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_56_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/00001648-199711000-00011","article-title":"Family history and risk of fatal prostate cancer","volume":"8","author":"Rodriguez C","year":"1997","journal-title":"Epidemiology"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.11466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.11466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:36:10Z","timestamp":1696797370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.11466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,4]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,12,10]]}},"alternative-id":["10.1002\/ijc.11466"],"URL":"https:\/\/doi.org\/10.1002\/ijc.11466","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,4]]}}}