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We investigated to see if this dysregulation could be due partly to thymus dysfunction by quantifying the number of signal joint T\u2010cell receptor excision circles (sjTRECs) in peripheral blood mononuclear cells of 30 untreated B\u2010CLL patients at diagnosis and in age\u2010matched healthy controls. sjTRECs were found decreased, normal and elevated in 19, 9 and 2 patients, respectively, in comparison to age\u2010matched controls. We next speculated that sjTREC levels might be related to an accredited B\u2010CLL prognostic marker represented by the somatic hypermutation (SHM) status of the variable heavy chain (V<jats:sub>H<\/jats:sub>) genes. Eight of 17 patients with SHMs had sjTREC levels in the range of or higher than normal donors, whereas only 3 of the 13 patients lacking SHMs had normal sjTREC levels. After a 5\u2010year observation period in 16 patients for whom a clinical follow\u2010up was available, only 2 of 10 patients with SHMs progressed <jats:italic>vs.<\/jats:italic> 5 of 6 patients without SHMs and 3 of 7 patients with normal or higher sjTREC levels progressed <jats:italic>vs<\/jats:italic>. 4 of 9 with low sjTREC levels. Our study demonstrates that sjTREC levels are decreased in &gt;60% of B\u2010CLL patients and suggests a potential role of thymus in the immune dysfunction of these patients. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.11482","type":"journal-article","created":{"date-parts":[[2004,1,24]],"date-time":"2004-01-24T23:45:04Z","timestamp":1074987904000},"page":"958-961","source":"Crossref","is-referenced-by-count":8,"title":["Thymic function and immunoglobulin mutation genotype in B\u2010cell chronic lymphocytic leukemia 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