{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:12:24Z","timestamp":1791180744940,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5356,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Cancer"],"published-print":{"date-parts":[[2001,9,1]]},"DOI":"10.1002\/ijc.1381","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:50:36Z","timestamp":1030312236000},"page":"653-661","source":"Crossref","is-referenced-by-count":67,"title":["Novel inactivating mutations of transforming growth factor-? type I receptor gene in head-and-neck cancer metastases"],"prefix":"10.1002","volume":"93","author":[{"given":"Taiping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Rimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"McNiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Leffell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001]]},"reference":[{"key":"10.1002\/ijc.1381-BIB1","first-page":"6705","volume":"47","author":"Reiss","year":"1987","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB2","first-page":"2068","volume":"46","author":"Shipley","year":"1986","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1002\/ijc.1381-BIB4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","volume":"67","author":"Massagu\u00e9","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/ijc.1381-BIB5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1002\/ijc.1381-BIB6","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/ki.1997.188","volume":"51","author":"Munger","year":"1997","journal-title":"Kidney Int"},{"key":"10.1002\/ijc.1381-BIB7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"10.1002\/ijc.1381-BIB8","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S1286-4579(99)00251-8","volume":"1","author":"Reiss","year":"1999","journal-title":"Microbes Infect"},{"key":"10.1002\/ijc.1381-BIB9","first-page":"493","volume":"4","author":"Fynan","year":"1993","journal-title":"Crit Rev Oncogenesis"},{"key":"10.1002\/ijc.1381-BIB10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/(SICI)1096-9896(199901)187:1<82::AID-PATH248>3.0.CO;2-8","volume":"187","author":"Akhurst","year":"1999","journal-title":"J Pathol"},{"key":"10.1002\/ijc.1381-BIB11","first-page":"235","volume-title":"Head and neck cancer: advances in basic research","volume":"1","author":"Garrigue-Antar","year":"1996","unstructured":"et al. The role of transforming growth factor-? receptors in cancer of the upper aero-digestive tract. In: Head and neck cancer: advances in basic research. Vol. 1. Kiel, Germany: Elsevier, 1996: 235-52."},{"key":"10.1002\/ijc.1381-BIB12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)80127-0","volume":"86","author":"Cui","year":"1996","journal-title":"Cell"},{"key":"10.1002\/ijc.1381-BIB13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.onc.1202161","volume":"17","author":"Amendt","year":"1998","journal-title":"Oncogene"},{"key":"10.1002\/ijc.1381-BIB14","first-page":"5564","volume":"57","author":"B\u00f6ttinger","year":"1997","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB15","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1093\/emboj\/16.10.2621","volume":"16","author":"Bottinger","year":"1997","journal-title":"EMBO J"},{"key":"10.1002\/ijc.1381-BIB16","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/sj.onc.1203701","volume":"19","author":"Go","year":"2000","journal-title":"Oncogene"},{"key":"10.1002\/ijc.1381-BIB17","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1073\/pnas.94.6.2386","volume":"94","author":"Wang","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/ijc.1381-BIB18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/carcin\/14.5.981","volume":"14","author":"Donnelly","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1002\/ijc.1381-BIB19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mc.2940040208","volume":"4","author":"Krieg","year":"1991","journal-title":"Mol Carcinogenesism"},{"key":"10.1002\/ijc.1381-BIB20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3727\/095535490820874029","volume":"2","author":"Reiss","year":"1990","journal-title":"Cancer Commun"},{"key":"10.1002\/ijc.1381-BIB21","first-page":"1986","volume":"58","author":"e","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB22","first-page":"3982","volume":"55","author":"Garrigue-Antar","year":"1995","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB23","first-page":"407","volume":"8","author":"Reiss","year":"1997","journal-title":"Cell Growth Differ"},{"key":"10.1002\/ijc.1381-BIB24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3727\/096504001108747639","volume":"12","author":"Yan","year":"2001","journal-title":"Oncology Res"},{"key":"10.1002\/ijc.1381-BIB25","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1093\/carcin\/18.11.2285","volume":"18","author":"Wang","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1002\/ijc.1381-BIB26","first-page":"2519","volume":"56","author":"Kim","year":"1996","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB27","first-page":"4805","volume":"58","author":"Chen","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/(SICI)1097-0215(19990702)82:1<43::AID-IJC9>3.0.CO;2-0","volume":"82","author":"Chen","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.1381-BIB29","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/geno.1997.5023","volume":"46","author":"Vellucci","year":"1997","journal-title":"Genomics"},{"key":"10.1002\/ijc.1381-BIB30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0092-8674(93)90489-D","volume":"75","author":"Franz\u00e9n","year":"1993","journal-title":"Cell"},{"key":"10.1002\/ijc.1381-BIB31","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1128\/MCB.14.6.3810","volume":"14","author":"Carcamo","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1002\/ijc.1381-BIB32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0092-8674(92)90395-S","volume":"71","author":"Wrana","year":"1992","journal-title":"Cell"},{"key":"10.1002\/ijc.1381-BIB33","doi-asserted-by":"crossref","first-page":"26750","DOI":"10.1074\/jbc.270.45.26750","volume":"270","author":"Li","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1002\/ijc.1381-BIB34","doi-asserted-by":"crossref","first-page":"11444","DOI":"10.1074\/jbc.272.17.11444","volume":"272","author":"Wells","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1002\/ijc.1381-BIB35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/1359-6101(96)00001-9","volume":"7","author":"Markowitz","year":"1996","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1002\/ijc.1381-BIB36","first-page":"447","volume":"9","author":"Reiss","year":"1997","journal-title":"Oncol Res"},{"key":"10.1002\/ijc.1381-BIB37","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1182\/blood.V94.8.2854.420k07_2854_2861","volume":"94","author":"Schiemann","year":"1999","journal-title":"Blood"},{"key":"10.1002\/ijc.1381-BIB38","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1074\/jbc.272.10.6423","volume":"272","author":"Koli","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1002\/ijc.1381-BIB39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.cb.05.110189.000245","volume":"5","author":"Pelham","year":"1989","journal-title":"Annu Rev Cell Biol"},{"key":"10.1002\/ijc.1381-BIB40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0065-3233(00)53002-2","volume":"53","author":"Serrano","year":"2000","journal-title":"Adv Protein Chem"},{"key":"10.1002\/ijc.1381-BIB41","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1073\/pnas.95.13.7412","volume":"95","author":"Xiang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/ijc.1381-BIB42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80555-3","volume":"96","author":"Huse","year":"1999","journal-title":"Cell"},{"key":"10.1002\/ijc.1381-BIB43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0076-6879(91)00126-H","volume":"200","author":"Hanks","year":"1991","journal-title":"Meth Enzymol"},{"key":"10.1002\/ijc.1381-BIB44","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.cb.08.110192.002241","volume":"8","author":"Taylor","year":"1992","journal-title":"Annu Rev Cell Biol"},{"key":"10.1002\/ijc.1381-BIB45","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nm0798-802","volume":"4","author":"Tang","year":"1998","journal-title":"Nat Med"},{"key":"10.1002\/ijc.1381-BIB46","first-page":"5678","volume":"59","author":"Pasche","year":"1999","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB47","first-page":"2727","volume":"58","author":"Pasche","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB48","first-page":"3363","volume":"59","author":"Anbazhagan","year":"1999","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.1381-BIB49","first-page":"19","volume":"17","author":"Fujiwara","year":"1998","journal-title":"Clin Neuropathol"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.1381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ijc.1381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T17:30:59Z","timestamp":1625160659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.1381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ijc.1381","relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}