{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T19:55:40Z","timestamp":1723492540426},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2004,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic alterations implicated in malignant melanoma are still poorly understood. Malignant melanomas present highly variable histologic and cytologic patterns. The aim of the present study is to define genomic imbalances associated with the development of 2 histologic types of swine hereditary cutaneous melanoma. We have investigated 11 swine tumors by comparative genomic hybridization (CGH), 4 superficial spreading melanomas (SSMs) and 7 nodular melanomas (NMs). Following laser capture microdissection and degenerate oligonucleotide primed\u2010polymerase chain reaction, we were able to isolate and then amplify DNA from the 2 histologic subtypes. Consensus regions of chromosome gains were identified on both histologic subtypes, on swine chromosomes 3p13\u2010p17 (75% of the SSMs and 71% of the NMs), 12q (100% of the SSMs and 57% of the NMs) and 14q11\u2010q21 (75% of the SSMs and 42% of NMs). Chromosomal loss was restricted to NM lesions and the swine 13q36\u201049 region was lost in 100% of the NMs. Interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization with a probe mapping to the 13q41\u2010q42 region indicates loss of the corresponding region on NM lesions. Taking into account this CGH analysis and the comparative genomic data between swine and human genomes, we suggest that a role for the human chromosomes 3p11\u2010qter and chromosome 21 losses should be investigated in human nodular melanoma progression. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20108","type":"journal-article","created":{"date-parts":[[2004,3,31]],"date-time":"2004-03-31T18:01:25Z","timestamp":1080756085000},"page":"232-238","source":"Crossref","is-referenced-by-count":9,"title":["Comparative genomic hybridization analysis of hereditary swine cutaneous melanoma revealed loss of the swine 13q36\u201049 chromosomal region in the nodular melanoma 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