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Omega\u20103 PUFAs in fish oil (FO) can inhibit the growth of human cancer cells <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. These effects are related to the uptake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the cellular substrate pool and their competitive metabolism with arachidonic acid (AA) at the cyclooxygenase and 5\u2010lipoxygenase levels. The metabolites of EPA and DHA have less inflammatory and immunosuppressant potency than the substances derived from AA. Based on previous experimental data, we hypothesized that FO supplementation after major abdominal cancer surgery would improve hepatic and pancreatic function. Ours was a prospective, randomized, double\u2010blinded clinical trial on 44 patients undergoing elective major abdominal surgery, randomly assigned to receive total parenteral nutrition (TPN) supplemented with either soybean oil (SO 1.0 g\/kg body weight daily, <jats:italic>n<\/jats:italic> = 20) for 5 days or a combination of FO and SO (FO 0.2 + SO 0.8 g\/kg body weight daily, <jats:italic>n<\/jats:italic> = 24). Compared to pure SO supplementation in the postoperative period, FO significantly reduced ASAT [0.8 \u00b1 0.1 <jats:italic>vs<\/jats:italic>. 0.5 \u00b1 0.1 mmol\/(l \u00b7 sec)], ALAT [0.9 \u00b1 0.1 <jats:italic>vs<\/jats:italic>. 0.6 \u00b1 0.1 mmol\/(l \u00b7 sec)], bilirubin (16.1 \u00b1 5.3 <jats:italic>vs<\/jats:italic>. 6.9 \u00b1 0.6 mmol\/l), LDH (7.7 \u00b1 0.4 <jats:italic>vs<\/jats:italic>. 6.7 \u00b1 0.4 mmol\/(l \u00b7 sec) and lipase (0.6 \u00b1 0.1 <jats:italic>vs<\/jats:italic>. 0.4 \u00b1 0.1 \u03bcmol\/(l \u00b7 sec) in the postoperative course. Moreover, patients with increased risk of sepsis (IL\u20106\/IL\u201010 ratio &gt;8) showed a tendency to shorter ICU stay (18 hr) under omega\u20103 PUFA treatment. Weight loss as encountered after the SO emulsion of 1.1 \u00b1 2.2 kg was absent in the FO group. After major abdominal tumor surgery, FO supplementation improved liver and pancreas function, which might have contributed to the faster recovery of patients. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20291","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T18:01:17Z","timestamp":1083693677000},"page":"611-616","source":"Crossref","is-referenced-by-count":140,"title":["Omega\u20103 fatty acids improve liver and pancreas function in postoperative cancer patients"],"prefix":"10.1002","volume":"111","author":[{"given":"Axel 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