{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:16:45Z","timestamp":1773152205960,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,8,25]],"date-time":"2004-08-25T00:00:00Z","timestamp":1093392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) infections and HPV\u2010associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population with non\u2010STD complaints. Penoscopy was performed after application of acetic acid to identify flat lesions, papular lesions, condylomata acuminata and pearly penile papules (PPPs). Presence of HPV DNA in penile scrapes was tested by GP5+6+ PCR. In case of HPV 16 positivity, viral loads were quantified using a LightCycler based real\u2010time PCR method. Comparing the non\u2010STD male hospital population (<jats:italic>n<\/jats:italic> = 118) with the male sexual partners of women with CIN (<jats:italic>n<\/jats:italic> = 238), flat penile lesions were found in 14% <jats:italic>vs<\/jats:italic>. 60% and penile HPV in 25% <jats:italic>vs<\/jats:italic>. 59% of the men, respectively. We found that the presence of penile HPV and, in case of HPV 16 positivity, higher viral loads were associated with the presence of flat penile lesions. Amongst the HPV\u2010positive men, flat penile lesions were more common and larger in size in male sexual partners of women with CIN than in the non\u2010STD hospital population. HPV infections and HPV\u2010associated flat penile lesions are commonly found in the non\u2010STD male population. However, these lesions are less frequently present and smaller in size than in male sexual partners of women with CIN. Higher viral loads in penile scrapes of male sexual partners of women with CIN are reflected by a higher prevalence of flat penile lesions and a larger size of these lesions.<\/jats:p>","DOI":"10.1002\/ijc.20502","type":"journal-article","created":{"date-parts":[[2004,8,25]],"date-time":"2004-08-25T17:06:59Z","timestamp":1093453619000},"page":"36-41","source":"Crossref","is-referenced-by-count":42,"title":["HPV\u2010associated flat penile lesions in men of a non\u2010STD hospital population: Less frequent and smaller in size than in male sexual partners of women with CIN"],"prefix":"10.1002","volume":"113","author":[{"given":"Maaike C.G.","family":"Bleeker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis J.A.","family":"Hogewoning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feja 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