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We investigated the microvascular structure of small lung metastases and the effect of JTE\u2010522, a selective COX\u20102 inhibitor, on the angiogenesis of pulmonary metastases from colorectal cancer in rats. The tail veins of 25 male F344\/DuCrj rats, aged 5 weeks, were injected with a tumor suspension containing 5 \u00d7 10<jats:sup>6<\/jats:sup> RCN\u20109, a rat colon cancer cell line. Three weeks later, pulmonary vascular resin corrosion casts were taken and the vascularity of metastases was studied using stereo and scanning electron microscopes. We investigated the effect of 0, 10 and 30 mg\/kg\/day of JTE\u2010522 on the angiogenesis of pulmonary metastases in 3 groups of 5 male rats out of 25. JTE\u2010522 reduced the diameter of tumor vessels as well as the number and size of metastatic tumors. The diameter of tumor vessels and the size of lung metastases significantly and positively correlated with neovascularization in the control group, but not in the JTE\u2010522\u2010treated groups. JTE\u2010522 also affected type of vasculature of metastases, which differed depending on their size. JTE\u2010522 interfered with the growth of hematogenous metastatic tumors by disrupting neovascularization. However, JTE\u2010522 may have some important mechanisms other than inhibition of neovascularization. JTE\u2010522 may be one of the therapeutic agents for the treatment of hematogenous metastasis of colorectal cancer. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20523","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T15:58:33Z","timestamp":1092931113000},"page":"920-926","source":"Crossref","is-referenced-by-count":11,"title":["JTE\u2010522, a selective COX\u20102 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: A vascular cast model 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