{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:39:58Z","timestamp":1773081598057,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T00:00:00Z","timestamp":1096329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic factors may be used not only to assess risk of prostate cancer development but also to evaluate prostate cancer outcomes including clinical prognosis, treatment methods, and treatment response. To assess the role of family history on prostate cancer outcomes, we evaluated tumor characteristics, diagnostic precursors and biochemical (prostate specific antigen) relapse\u2010free survival in men with and without a family history of prostate cancer. A total of 684 prostate cancer cases unselected for family history were identified from an ongoing hospital based prostate cancer case\u2010control study between 1995 and 2002. Self\u2010reported family history was grouped within the following categories: none, any, moderate (one affected first or second degree relative) and high (2 or more affected first or second degree relatives). We further considered groups defined by early (before age 60) and late (after age 60) age at diagnosis. Overall, tumor stage was not significantly associated with any (odds ratio [OR] = 1.43 95% confidence interval [CI] = 1.00\u20132.05) or moderate (OR = 1.48, 95% CI = 1.0\u20102.19) family histories. Men diagnosed before age 60, however, had higher tumor stages if they had any (OR = 2.19, 95% CI = 1.28\u20133.75) or moderate (OR = 2.15, 95% CI = 1.2\u20133.9) family histories. Men diagnosed after age 60 with any family history were significantly more likely to experience biochemical (PSA) failure (Hazard ratio [HR] = 2.60, 95%CI = 1.08\u20136.25). Men with any and moderate family histories were at significantly increased risk of biochemical failure (HR = 2.49, 95%CI = 1.25\u20134.95 and HR = 2.46, 95% CI = 1.17\u20135.16, respectively). Moderate family history increased probability of seminal vesicle invasion (OR = 2.14, 95%CI = 1.06\u20134.34). Our results suggest that a family history of prostate cancer may be associated with predictors of clinical outcome in prostate cancer cases unselected for a family history of prostate cancer.<\/jats:p>","DOI":"10.1002\/ijc.20578","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T21:01:48Z","timestamp":1096405308000},"page":"471-474","source":"Crossref","is-referenced-by-count":17,"title":["Association of prostate cancer family history with histopathological and clinical characteristics of prostate tumors"],"prefix":"10.1002","volume":"113","author":[{"given":"E.","family":"Spangler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Zeigler\u2010Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.B.","family":"Malkowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Wein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.R.","family":"Rebbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,28]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Prostate cancer trends 1973\u20131995","author":"Stanford JL","year":"1999"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_5_4_2","first-page":"2739","article-title":"Clinical characteristics of prostate cancer in an analysis of linkage for four putative susceptibility loci","volume":"7","author":"Goode EL","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a000789"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/316916"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1478"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0022-5347(17)35617-3","article-title":"Hereditary prostate cancer: epidemiological and clinical features","volume":"150","author":"Carter BS","year":"1993","journal-title":"J Urol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67619-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66024-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00103-4"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170409"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67063-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00168.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68194-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/00001648-199711000-00011","article-title":"Family history and risk of fatal prostate cancer","volume":"8","author":"Rodriguez C","year":"1997","journal-title":"Epidemiology"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000019672"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64997-X"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62748-4"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1998.00801.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65173-7"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.20578","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.20578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:24:40Z","timestamp":1697217880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.20578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,28]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,1,20]]}},"alternative-id":["10.1002\/ijc.20578"],"URL":"https:\/\/doi.org\/10.1002\/ijc.20578","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,28]]}}}