{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:53:36Z","timestamp":1762296816244},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T00:00:00Z","timestamp":1098316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beyond human papillomavirus (HPV) infection, host genetic factors may contribute to cervical carcinogenesis. This study aims to test the hypothesis that CA\u2010dinucleotide repeat polymorphism in the first intron of the interferon\u2010gamma (<jats:italic>IFN<\/jats:italic>\u2010\u03b3) gene is associated with HPV\u2010initiated cervical carcinogenesis. A hospital\u2010based case\u2010control study including patients with low\u2010grade squamous intraepithelial lesions (LSILs; <jats:italic>n<\/jats:italic> = 93), high\u2010grade squamous intraepithelial lesions (HSILs; <jats:italic>n<\/jats:italic> = 123) and invasive carcinomas (<jats:italic>n<\/jats:italic> = 153) of the uterine cervix, as well as 1:1 age\u2010matched controls, was conducted. The <jats:italic>IFN<\/jats:italic>\u2010\u03b3 genotype was determined by PCR and capillary electrophoresis with internal standards. HPV genotype was determined by consensus PCR and reverse line blot hybridization. Genotypes containing the 12 or 14 allele (12 or 14 CA repeats) were significantly more common in patients with HSILs than in controls (46% <jats:italic>vs.<\/jats:italic> 22%; OR = 3.0; 95% CI = 1.7\u20135.2; <jats:italic>p<\/jats:italic> &lt; 0.0001). In contrast, genotypes containing 13 and 18 were significantly more common in controls than in patients with HSILs (76% <jats:italic>vs.<\/jats:italic> 53%; OR = 0.3; 95% CI = 0.2\u20130.6; <jats:italic>p<\/jats:italic> = 0.0001) or squamous cell carcinomas (74% <jats:italic>vs.<\/jats:italic> 63%; OR = 0.6; 95% CI = 0.4\u20131.0; <jats:italic>p<\/jats:italic> = 0.037). The frequency of the 12 and 14 genotypes increased significantly in accordance with the severity of cervical carcinogenesis (<jats:italic>p<\/jats:italic><jats:sub>test for trend<\/jats:sub> = 0.0002), whereas the 13 and 18 genotypes showed the opposite trend (<jats:italic>p<\/jats:italic><jats:sub>test for trend<\/jats:sub> = 0.007). Comparing IFN\u2010\u03b3 genotype and HPV status, 18\u2010containing genotypes were more frequently found in HPV<jats:sup>+<\/jats:sup> LSILs, and 12\u2010containing genotypes were less frequently found in HPV<jats:sup>+<\/jats:sup> HSILs. Compared with non\u201013 genotypes, 13 genotype HSILs were more frequently infected with HPV58 (70% <jats:italic>vs.<\/jats:italic> 45%) and less frequently infected with HPV18 (0% <jats:italic>vs.<\/jats:italic> 16%; <jats:italic>p<\/jats:italic>= 0.007). Genetic polymorphism of the <jats:italic>IFN<\/jats:italic>\u2010\u03b3 gene is associated with individual susceptibility to cervical carcinogenesis. This polymorphism correlates with HPV infection in a disease\u2010 and type\u2010specific manner. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20637","type":"journal-article","created":{"date-parts":[[2004,10,23]],"date-time":"2004-10-23T11:39:26Z","timestamp":1098531566000},"page":"712-718","source":"Crossref","is-referenced-by-count":26,"title":["Genetic polymorphism of the <i>interferon<\/i>\u2010\u03b3 gene in cervical 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