{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:50:09Z","timestamp":1791355809679,"version":"4.3.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3960,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias","award":["FIS-01\/1125"],"award-info":[{"award-number":["FIS-01\/1125"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["FIS-02\/1025"],"award-info":[{"award-number":["FIS-02\/1025"]}]},{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["SAF2001-2361"],"award-info":[{"award-number":["SAF2001-2361"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FIS"},{"name":"Fundaci\u00f3n Carolina"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Cancer"],"published-print":{"date-parts":[[2005,3,1]]},"DOI":"10.1002\/ijc.20656","type":"journal-article","created":{"date-parts":[[2004,11,7]],"date-time":"2004-11-07T13:05:44Z","timestamp":1099832744000},"page":"899-910","source":"Crossref","is-referenced-by-count":234,"title":["Characterization of human PA2.26 antigen (T1\u03b1-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas"],"prefix":"10.1002","volume":"113","author":[{"given":"Ester","family":"Mart\u00edn-Villar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco G.","family":"Scholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gamallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Yurrita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mu\u00f1oz-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Cruces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Quintanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,28]]},"reference":[{"key":"10.1002\/ijc.20656-BIB1|cit2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3322\/canjclin.49.1.33","article-title":"Global cancer statistics","volume":"49","author":"Parkin","year":"1999","journal-title":"CA Cancer J Clin"},{"key":"10.1002\/ijc.20656-BIB2|cit3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3322\/canjclin.52.4.195","article-title":"Oral cancer and precancerous lesions","volume":"52","author":"Neville","year":"2002","journal-title":"CA Cancer J Clin"},{"key":"10.1002\/ijc.20656-BIB3|cit4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/10454411010120010401","article-title":"New approaches to the understanding of the molecular basis of oral cancer","volume":"12","author":"Patel","year":"2001","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1002\/ijc.20656-BIB4|cit5","first-page":"2977","article-title":"Molecular aspects of oral cancer","volume":"22","author":"Nagler","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1002\/ijc.20656-BIB5|cit6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1098-2744(199709)20:1<10::AID-MC3>3.0.CO;2-M","article-title":"Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis","volume":"20","author":"Gandarillas","year":"1997","journal-title":"Mol Carcinog"},{"key":"10.1002\/ijc.20656-BIB6|cit7","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1242\/jcs.112.24.4601","article-title":"Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes","volume":"112","author":"Scholl","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1002\/ijc.20656-BIB7|cit8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/dbio.1995.1024","article-title":"Cloning, characterization, and developmental expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives","volume":"167","author":"Rishi","year":"1995","journal-title":"Dev Biol"},{"key":"10.1002\/ijc.20656-BIB8|cit9","first-page":"1141","article-title":"Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis","volume":"151","author":"Breiteneder-Geleff","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1002\/ijc.20656-BIB9|cit10","first-page":"511","article-title":"Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells","volume":"1","author":"Nose","year":"1990","journal-title":"Cell Growth Differ"},{"key":"10.1002\/ijc.20656-BIB10|cit11","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1084\/jem.176.5.1477","article-title":"Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues","volume":"176","author":"Farr","year":"1992","journal-title":"J Exp Med"},{"key":"10.1002\/ijc.20656-BIB11|cit12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jnr.10696","article-title":"Complementary DNA cloning and characterization of RANDAM-2, a type I membrane molecule specifically expressed on glutamatergic neuronal cells in the mouse cerebrum","volume":"73","author":"Kotani","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1002\/ijc.20656-BIB12|cit13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1165\/ajrcmb.14.6.8652186","article-title":"T1\u03b1 protein is developmentally regulated and expressed by alveolar type I cells, choroids plexus, and ciliary epithelia of adult rats","volume":"14","author":"Williams","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/ijc.20656-BIB13|cit14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0167-4838(98)00231-3","article-title":"Purification and analysis of RT140, a type I alveolar epithelial cell apical membrane protein","volume":"1429","author":"Gonzalez","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/ijc.20656-BIB14|cit15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/8756-3282(95)00457-2","article-title":"Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes","volume":"18","author":"Wetterwald","year":"1996","journal-title":"Bone"},{"key":"10.1002\/ijc.20656-BIB15|cit16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bj3260099","article-title":"Molecular characterization of gp40, a mucin-type glycoprotein from the apical plasma membrane of Madin-Darby canine kidney cells (type I)","volume":"326","author":"Zimmer","year":"1997","journal-title":"Biochem J"},{"key":"10.1002\/ijc.20656-BIB16|cit17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/bj3410277","article-title":"Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium","volume":"341","author":"Zimmer","year":"1999","journal-title":"Biochem J"},{"key":"10.1002\/ijc.20656-BIB17|cit18","doi-asserted-by":"crossref","first-page":"51599","DOI":"10.1074\/jbc.M309935200","article-title":"Molecular identification of Aggrus\/T1\u03b1 as a platelet aggregation-inducing factor expressed in colorectal tumors","volume":"278","author":"Kato","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1002\/ijc.20656-BIB18|cit19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0012-1606(02)00098-2","article-title":"T1\u03b1, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth","volume":"256","author":"Ramirez","year":"2003","journal-title":"Dev Biol"},{"key":"10.1002\/ijc.20656-BIB19|cit20","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/emboj\/cdg342","article-title":"T1\u03b1\/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema","volume":"22","author":"Schacht","year":"2003","journal-title":"EMBO J"},{"key":"10.1002\/ijc.20656-BIB20|cit21","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/labinvest.3780185","article-title":"Ectopic expression of PA2.26 antigen in epidermal keratinocytes leads to destabilization of adherens junctions and malignant progression","volume":"80","author":"Scholl","year":"2000","journal-title":"Lab Invest"},{"key":"10.1002\/ijc.20656-BIB21|cit22","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/ijc.20656-BIB22|cit23","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1242\/jcs.105.4.923","article-title":"Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin","volume":"105","author":"Navarro","year":"1993","journal-title":"J Cell Sci"},{"key":"10.1002\/ijc.20656-BIB23|cit24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1083\/jcb.140.4.885","article-title":"Ezrin\/radixin\/moesin (ERM)-binding proteins bind to a positively charged amino acid cluster in the yuxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2","volume":"140","author":"Yonemura","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1002\/ijc.20656-BIB24|cit25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1165\/ajrcmb.19.1.2953","article-title":"Evidence against a role of mouse, rat, and two cloned human T1\u03b1 isoforms as a water channel or a regulator of aquoporin-type water channels","volume":"19","author":"Ma","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/ijc.20656-BIB25|cit26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nrm882","article-title":"ERM proteins and merlin: integrators at cell cortex","volume":"8","author":"Bretscher","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1002\/ijc.20656-BIB26|cit27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0092-8674(00)81281-7","article-title":"Actin-based cell motility and cell locomotion","volume":"84","author":"Mitchison","year":"1996","journal-title":"Cell"},{"key":"10.1002\/ijc.20656-BIB27|cit28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0962-8924(01)02237-1","article-title":"The lamellipodium: where motility begins","volume":"12","author":"Small","year":"2002","journal-title":"Trends Cell Biol"},{"key":"10.1002\/ijc.20656-BIB28|cit29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3835(97)00308-X","article-title":"Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines","volume":"120","author":"Denk","year":"1997","journal-title":"Cancer Lett"},{"key":"10.1002\/ijc.20656-BIB29|cit30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0959-8049(02)00175-2","article-title":"E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours","volume":"39","author":"Chen","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.1002\/ijc.20656-BIB30|cit31","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1084\/jem.194.6.797","article-title":"Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages","volume":"194","author":"Kriehuber","year":"2001","journal-title":"J Exp Med"},{"key":"10.1002\/ijc.20656-BIB31|cit32","first-page":"1178","article-title":"The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis-Thirty-third GHA Clowes Memorial Award Lecture","volume":"54","author":"Yuspa","year":"1994","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.20656-BIB32|cit33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/mp.53.4.165","article-title":"Molecular pathogenesis of oral squamous carcinoma","volume":"53","author":"Williams","year":"2000","journal-title":"J Clin Pathol Mol Pathol"},{"key":"10.1002\/ijc.20656-BIB33|cit34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1097-0215(19960117)65:2<254::AID-IJC21>3.0.CO;2-C","article-title":"Expression pattern of the cell adhesion molecules E-cadherin, P-cadherin and \u03b16\u03b24 integrin is altered in pre-malignant skin tumors of p53-deficient mice","volume":"65","author":"Cano","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.20656-BIB34|cit35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1096-9896(199809)186:1<8::AID-PATH156>3.0.CO;2-H","article-title":"Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity","volume":"186","author":"Bagutti","year":"1998","journal-title":"J Pathol"},{"key":"10.1002\/ijc.20656-BIB35|cit36","first-page":"3817","article-title":"\u03b2- and \u03b3-catenin expression in oral squamous cell carcinomas","volume":"19","author":"Lo Muzio","year":"1999","journal-title":"Anticancer Res"},{"key":"10.1002\/ijc.20656-BIB36|cit37","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1034\/j.1600-0714.2002.00147.x","article-title":"Deranged expression of E-cadherin\/\u03b2-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas","volume":"31","author":"Bankfalvi","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"10.1002\/ijc.20656-BIB37|cit38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/sj.bjc.6601124","article-title":"Expression of E-cadherin, \u03b1-catenin, and \u03b2-catenin in the process of lymph node metastasis in oral squamous cell carcinoma","volume":"89","author":"Tanaka","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1002\/ijc.20656-BIB38|cit39","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/ijc.1386","article-title":"The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas","volume":"93","author":"Nakayama","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.20656-BIB39|cit40","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/cncr.10211","article-title":"Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance","volume":"94","author":"Chang","year":"2002","journal-title":"Cancer"},{"key":"10.1002\/ijc.20656-BIB40|cit41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ijc.11028","article-title":"Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma","volume":"20","author":"Viswanathan","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.20656-BIB41|cit42","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrc1213","article-title":"Merlin and ERM proteins: unappreciated roles in cancer development?","volume":"3","author":"McClatchey","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/ijc.20656-BIB42|cit43","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1091\/mbc.E02-07-0410","article-title":"Ezr\u00edn regulates E-cadherin-dependent adherens junction assembly through Rac1 activation","volume":"14","author":"Pujuguet","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1002\/ijc.20656-BIB43|cit44","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/(SICI)1098-2744(199811)23:3<144::AID-MC3>3.0.CO;2-U","article-title":"Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes","volume":"23","author":"Fusenig","year":"1998","journal-title":"Mol Carcinog"},{"key":"10.1002\/ijc.20656-BIB44|cit45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1073\/pnas.012425299","article-title":"Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis","volume":"99","author":"Ino","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/ijc.20656-BIB45|cit46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0968-0004(92)90315-Z","article-title":"Cell membrane-associated mucins and their adhesion-modulating properties","volume":"17","author":"Hilkens","year":"1992","journal-title":"Trends Biochem Sci"},{"key":"10.1002\/ijc.20656-BIB46|cit47","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.ph.57.030195.003135","article-title":"Epithelial mucin genes","volume":"57","author":"Gendler","year":"1995","journal-title":"Annu Rev Physiol"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.20656","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ijc.20656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T18:08:12Z","timestamp":1625162892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.20656"}},"subtitle":["PA2.26 Antigen and Oral Squamous Cell Carcinoma"],"short-title":[],"issued":{"date-parts":[[2004,10,28]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ijc.20656","archive":["Portico"],"relation":{},"ISSN":["0020-7136"],"issn-type":[{"value":"0020-7136","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10,28]]}}}