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In a population\u2010based case\u2010control study of San Francisco Bay area women, we analyzed interview data by tumor EBV status. Among 211 young adult cases, EBV\u2010positive HL (11%) was associated with a single <jats:italic>vs.<\/jats:italic> shared bedroom at age 11 (OR = 4.0, 95% CI 1.1\u201314.4); risk was decreased for common childhood infections (OR = 0.3, 95% CI 0.1\u20131.0), including measles before age 10, but not with prior infectious mononucleosis (IM), which is delayed EBV infection. No study factors affected risk of young adult EBV\u2010negative HL. Among 57 older adult cases, EBV\u2010positive HL (23%) was unrelated to study factors; EBV\u2010negative HL was associated with a single bedroom at age 11 (OR = 3.6, 95% CI 1.5\u20139.1) and IM in family members (OR = 3.1, 95% CI 1.1\u20139.0). Thus, delayed exposure to infection may increase risk of EBV\u2010positive HL in young adults, but risk patterns differ in younger and older women for both EBV\u2010positive and \u2010negative HL. Late EBV infection does not appear relevant to risk, suggesting that other pathogens impact HL etiology in affluent female populations. Inconsistency of findings with prior studies may reflect failure of study risk factors to proxy meaningful exposures, risk differences by gender, or selection or misclassification bias. Null findings for EBV\u2010negative HL indicate that etiologic models should be reconsidered for this common form. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20787","type":"journal-article","created":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T16:21:05Z","timestamp":1107793265000},"page":"599-605","source":"Crossref","is-referenced-by-count":25,"title":["Exposure to childhood infections and risk of Epstein\u2010Barr virus\u2013defined Hodgkin's lymphoma in women"],"prefix":"10.1002","volume":"115","author":[{"given":"Sally L.","family":"Glaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa H. 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