{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:09:04Z","timestamp":1762322944966},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to evaluate automation\u2010assisted screening, in comparison to the conventional method, in a routine population\u2010based cervical cancer\u2010screening programme. Our study is based on an individually randomised design involving approximately 160,000 invitees and 110,000 attendees every year. From 1999 to 2001, 471,297 women were invited to attend and 330,445 smears were screened (attendance rate 70.1%), of which 220,254 were tested conventionally and 110,191 were tested using the automation\u2010assisted method. Cytologic Papanicolaou group II findings were reported slightly more often (RR = 1.04) in the automation\u2010assisted method than in the conventional screening arm. There were 1,291 cases of histologically confirmed dysplasia or carcinoma (0.4% of the screened), one\u2010third of which were severe dysplasia or a more severe finding (CIN3+). The detection rates of histologically verified findings were similar between the 2 screening arms. In Finland, the screening programme has been effective. As the detection rates, particularly of CIN3+, were similar between the screening arms, we will continue the automation\u2010assisted method in the routine screening programme. Further follow\u2010up for interval cancer incidence is required, however, to measure if the effect of screening is the same between the arms. A similar evaluation design is feasible to any other major or competing modification of the screening test or other element in the programme. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20902","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T00:17:43Z","timestamp":1107303463000},"page":"307-311","source":"Crossref","is-referenced-by-count":13,"title":["A randomised public\u2010health trial on automation\u2010assisted screening for cervical cancer in Finland: Performance with 470,000 invitations"],"prefix":"10.1002","volume":"115","author":[{"given":"Pekka","family":"Nieminen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kotaniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Hakama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Tarkkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Martikainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terttu","family":"Toivonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Ikkala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapio","family":"Luostarinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahti","family":"Anttila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1968.tb00136.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112253"},{"key":"e_1_2_6_4_2","first-page":"279","volume-title":"Trends in cancer incidence","author":"Hakama M","year":"1982"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92695-X"},{"key":"e_1_2_6_6_2","first-page":"2157","article-title":"Effect of organised screening on incidence and mortality of cervical cancer in Denmark","volume":"49","author":"Lynge E","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<59::AID-IJC12>3.0.CO;2-N"},{"key":"e_1_2_6_8_2","volume-title":"Evaluation and monitoring of screening programmes","author":"Sankila R","year":"2000"},{"key":"e_1_2_6_9_2","volume-title":"Cancer incidence in Finland 2000 and 2001","author":"Finnish Cancer Registry","year":"2003"},{"key":"e_1_2_6_10_2","series-title":"Cancer incidence in five continents","author":"Parkin DM","year":"2002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<112::AID-CNCR16>3.0.CO;2-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10839"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00311-7"},{"key":"e_1_2_6_14_2","volume-title":"The design and analysis of cohort studies","author":"Breslow NE","year":"1987"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780040211"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00259-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00210.x"},{"key":"e_1_2_6_18_2","first-page":"995","article-title":"The diagnostic value of computer\u2010assisted primary cervical smear screening: a longitudinal cohort study","volume":"12","author":"Doornewaard H","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_6_19_2","first-page":"151","article-title":"Papnet\u2010assisted,primary screening of cervico\u2010vaginal smears","volume":"44","author":"Duggan MA","year":"2000","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<1017::AID-SIM508>3.0.CO;2-V"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jms.6.2.103"},{"key":"e_1_2_6_22_2","unstructured":"MossSM GrayA LegoodR HenstockE. 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