{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:21:37Z","timestamp":1791145297053,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T00:00:00Z","timestamp":1107734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DNA repair is central to normal cellular functions, and polymorphisms of DNA repair genes may cause variation in DNA repair capacity in the general population. Newly identified polymorphisms of xeroderma pigmentosum group C (<jats:italic>XPC<\/jats:italic>), one of the nucleotide excision repair genes, were shown to contribute to genetic susceptibility to cancer. In this study, we hypothesized that 2 exonic variants C499T and A939C and their haplotypes in <jats:italic>XPC<\/jats:italic> are associated with lung cancer risk. To test this hypothesis, we performed a case\u2010control study of 320 histologically confirmed lung cancer patients and 322 age and sex frequency\u2010matched cancer\u2010free controls in a Chinese population. Multivariate logistic regression analyses revealed that the risks [adjusted odds ratios (ORs) and 95% confidence intervals (CIs)] associated with the <jats:italic>XPC<\/jats:italic> variant genotypes were 1.57 (95% CI = 1.13\u20132.19) for 499CT\/TT and 1.21 (95% CI = 0.87\u20131.69) for 939AC\/CC compared with the 499CC and 939AA wild\u2010type homozygotes, respectively. Individuals with both putative risk genotypes (499CT\/TT and 939AC\/CC) had a greater risk of lung cancer (adjusted OR = 2.37; 95% CI = 1.33\u20134.21) compared with individuals with both wild\u2010type genotypes (499CC and 939AA). When we performed the haplotype analysis and assumed the <jats:italic>XPC<\/jats:italic> 499T and 939C as risk alleles, the adjusted ORs increased as the number of variants in the haplotype genotypes increased (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub> &lt; 0.001). In the stratified analysis, the greatest risk was found in smokers having the combined variant genotypes (adjusted OR = 7.36; 95% CI = 3.19\u201317.00) compared with nonsmokers having both wild\u2010type genotypes and in smokers with 2 or 3 haplotype variants (adjusted OR = 7.27; 95% CI = 3.37\u201315.68) compared with nonsmokers having 0 haplotype variant. These findings indicate that <jats:italic>XPC<\/jats:italic> exonic variants may contribute to the risk of lung cancer in the Chinese population, and these variant genotypes may modulate the risk of lung cancer associated with smoking. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20911","type":"journal-article","created":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T16:18:28Z","timestamp":1107793108000},"page":"478-483","source":"Crossref","is-referenced-by-count":86,"title":["DNA repair gene <i>XPC<\/i> genotypes\/haplotypes and risk of lung cancer in a Chinese population"],"prefix":"10.1002","volume":"115","author":[{"given":"Zhibin","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaochu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,7]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Tobacco 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