{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:28:15Z","timestamp":1761596895708},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T00:00:00Z","timestamp":1109116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously found that an extracellular polysaccharide, AC\u20101, produced by <jats:italic>Acetobacter polysaccharogenes<\/jats:italic> composed of (1,4)\u2010\u03b2\u2010D\u2010glucan with branches of glucosyl residues showed a strong activity to induce production of interleukin (IL)\u201012 p40 and tumor necrosis factor\u2010\u03b1 by macrophage cell lines <jats:italic>in vitro<\/jats:italic> via Toll\u2010like receptor\u20104 signaling. In the present study, we examined the effects of oral administration of AC\u20101 on protection against 2 types of murine B16 melanoma lines, major histocompatibility complex (MHC) class I\u2010negative B16L and MHC class I gene\u2010transfected B16K<jats:sup>b<\/jats:sup> cells. Mice were inoculated subcutaneously with B16L or B16K<jats:sup>b<\/jats:sup> cells on day 0 and administrated intragastrically with AC\u20101 or PBS once every 5 days from 1 day before tumor inoculation. The tumor growth was severely retarded in AC\u20101\u2010treated mice after subcutaneous inoculation with B16L or B16K<jats:sup>b<\/jats:sup> cells. The AC\u20101\u2010treated mice showed augmented natural killer (NK) cell activity against B16L cells, and <jats:italic>in vivo<\/jats:italic> depletion of NK cells by antiasialoGM1 antibody (Ab) treatment abrogated the antitumor activity in AC\u20101\u2010treated mice. On the other hand, AC\u20101\u2010treated mice inoculated with B16K<jats:sup>b<\/jats:sup> cells developed a significantly higher level of cytotoxic T\u2010lymphocyte response against B16K<jats:sup>b<\/jats:sup> cells, and <jats:italic>in vivo<\/jats:italic> depletion of CD8<jats:sup>+<\/jats:sup> T cells by anti\u2010CD8 mAb treatment abrogated the antitumor activity. Thus, AC\u20101 augmented antitumor activity against different tumors via augmentation of different antitumor mechanisms. These results suggest a possible prophylactic application of AC\u20101 for human neoplasms irrespective of expression levels of their MHC class I molecules. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20934","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T20:19:05Z","timestamp":1109189945000},"page":"769-776","source":"Crossref","is-referenced-by-count":19,"title":["Soluble branched (1,4)\u2010\u03b2\u2010D\u2010glucans from <i>Acetobacter<\/i> species enhance antitumor activities against MHC class I\u2010negative and \u2010positive malignant melanoma through augmented NK activity and cytotoxic T\u2010cell response"],"prefix":"10.1002","volume":"115","author":[{"given":"Yoriyuki","family":"Kamiryo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimika","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Yoshikai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2776","article-title":"Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) 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