{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:10:46Z","timestamp":1771013446762,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is strong evidence of a protection of high consumption of plant foods against squamous cell carcinoma of the oesophagus, but the respective role of fruits and vegetables is not well elucidated. In the time period 1996\u20132003, a case\u2010control study designed in order to address this question was conducted in Uruguay. The study included 200 cases and 400 age\u2010 and sex\u2010matched controls. High total vegetable and total fruit consumption was the strongest protective food group for this malignancy (OR 0.31, 95% CI 0.18\u20130.51). When this food group was dissected in total vegetables and total fruits, the latter item was more protective than the former one (OR for total fruits 0.48, 95% CI 0.35\u20130.66) (<jats:italic>p<\/jats:italic>\u2010value for difference between both variables 0.04). Finally, when total fruits were dissected in citrus fruits and other fruits, citrus fruits were strongly associated with a reduction in risk (OR 0.47, 95% CI 0.34\u20130.67). The results of our study point towards an important role of fruits in the prevention of squamous cell carcinoma of the oesophagus. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20950","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T18:48:27Z","timestamp":1110307707000},"page":"130-135","source":"Crossref","is-referenced-by-count":27,"title":["The role of vegetable and fruit consumption in the aetiology of squamous cell carcinoma of the oesophagus: A case\u2010control study in Uruguay"],"prefix":"10.1002","volume":"116","author":[{"given":"Eduardo","family":"De Stefani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Deneo\u2010Pellegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro L.","family":"Ronco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelayo","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Mendilaharsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,8]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Incidencia del c\u00e1ncer en el Uruguay 1991","author":"Vassallo JA","year":"1996"},{"key":"e_1_2_5_3_2","volume-title":"II Atlas de incidencia del c\u00e1ncer en el Uruguay 1996\u20131997","author":"Vasallo JA","year":"2001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.465"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910560505"},{"key":"e_1_2_5_6_2","volume-title":"Cancer in Italian migrant populations","author":"Buiatti E","year":"1993"},{"key":"e_1_2_5_7_2","first-page":"426","article-title":"Mate drinking,alcohol, tobacco, diet and esophageal cancer in Uruguay: a case\u2010control study","volume":"50","author":"De Stefani E","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_5_8_2","first-page":"1","article-title":"Diet and risk of cancer of the upper aerodigestive tract\u2010I. Foods","volume":"35","author":"De Stefani E","year":"1998","journal-title":"Oral Oncol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990702)82:1<33::AID-IJC7>3.0.CO;2-7"},{"key":"e_1_2_5_10_2","first-page":"23","article-title":"Vegetables,fruits, related dietary antioxidants and risk of squamous cell carcinoma of the esophagus: a case\u2010control study in Uruguay","volume":"28","author":"De Stefani E","year":"2001","journal-title":"Nutr Cancer"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601239"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00051313","article-title":"Retrospective cohort study of risk factors for oesophageal cancer in Linxian, People's Republic of China","volume":"4","author":"Yu Y","year":"1993","journal-title":"Cancer Causes Control"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.3.444"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600775"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20616"},{"key":"e_1_2_5_16_2","first-page":"1199","article-title":"Esophageal cancer among black men in Washington DC. II. Role of nutrition","volume":"67","author":"Ziegler RG","year":"1981","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.20.1620"},{"key":"e_1_2_5_18_2","first-page":"140","article-title":"Adenocarcinoma of the esophagus: role of obesity and diet","volume":"87","author":"Brown LM","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008861806923"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910390610"},{"key":"e_1_2_5_21_2","first-page":"557","article-title":"Alcohol, tobacco, diet, mate drinking, and esophageal cancer in Argentina","volume":"3","author":"Castelletto R","year":"1994","journal-title":"Cancer Epidemiol. Biomarkers Prev"},{"key":"e_1_2_5_22_2","first-page":"595","article-title":"Hot and cold mate drinking and esophageal cancer in Paraguay. Cancer Epidemiol","volume":"4","author":"Rol\u00f3n PA","year":"1995","journal-title":"Biomarkers Prev"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001115)88:4<658::AID-IJC22>3.0.CO;2-T"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635588709513915"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980330)76:1<7::AID-IJC2>3.0.CO;2-4"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635588709513938"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.17.1407"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480307"},{"key":"e_1_2_5_29_2","first-page":"87","article-title":"Risk factors for esophageal cancer in lifelong nonsmokers. Cancer Epidemiol","volume":"3","author":"Tavani A","year":"1994","journal-title":"Biomarkers Prev"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000715)87:2<289::AID-IJC22>3.0.CO;2-9"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200008000-00005"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<300::AID-IJC6>3.0.CO;2-5"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1979.54"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91960-G"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2147"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200108000-00010"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1159\/000055142"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635588709513945"},{"key":"e_1_2_5_39_2","first-page":"335","article-title":"The etiological role of diet,smoking, and drinking habits in patients with esophageal carcinoma in Turkey","volume":"11","author":"Memik F","year":"1992","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914nc392_7"},{"key":"e_1_2_5_41_2","first-page":"1290","article-title":"Risk factors for esophageal cancer in eastern Anatolia","volume":"49","author":"Onuk MD","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_42_2","first-page":"2268","article-title":"An epidemiological study of precursor lesions of esophageal cancer among young persons in a high\u2010risk in Huixian, China","volume":"50","author":"Chang\u2010Claude JC","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430502"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910580209"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570108"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1121"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.6.1060"},{"key":"e_1_2_5_48_2","volume-title":"Statistical methods in cancer research, Vol. I. The analysis of case\u2010control studies","author":"Breslow NE","year":"1980"},{"key":"e_1_2_5_49_2","volume-title":"Stata user's guide and reference manual, release 6","author":"STATA","year":"1999"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00115636"},{"key":"e_1_2_5_51_2","volume-title":"Food, nutrition and the prevention of cancer: a global perspective","author":"World Cancer Research Fund","year":"1997"},{"key":"e_1_2_5_52_2","series-title":"IARC Handbooks of cancer prevention","volume-title":"Fruit and vegetables","year":"2003"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_5_54_2","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/oxfordjournals.aje.a114190","article-title":"Regression modeling of consumption of exposure variables classified by type","volume":"122","author":"Dorfman A","year":"1985","journal-title":"Am J Epidemiol"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116647"},{"key":"e_1_2_5_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.12.1113"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199202000-00002"},{"key":"e_1_2_5_58_2","series-title":"Nutritional epidemiology","author":"Willett WC","year":"1998"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.20950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.20950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:22:29Z","timestamp":1697242949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.20950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,8]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,8,10]]}},"alternative-id":["10.1002\/ijc.20950"],"URL":"https:\/\/doi.org\/10.1002\/ijc.20950","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,8]]}}}