{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:30:07Z","timestamp":1791045007240,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T00:00:00Z","timestamp":1109116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Survivin, a unique member of the inhibitor of apoptosis protein family, is overexpressed in many cancers and considered to play an important role in oncogenesis. We previously reported the survivin expression profile in ATL, a CD4\u2010positive T\u2010cell malignancy caused by HTLV\u2010I. HTLV\u2010I Tax is thought to play an important role in immortalization of T cells. We have shown also that the expression of Tax protected the mouse T\u2010cell line CTLL\u20102 against apoptosis induced by deprivation of IL\u20102 and converted its growth from being IL\u20102 dependent to being IL\u20102 independent through the NF\u2010\u03baB pathway. In our study, we demonstrate that constitutive expression of survivin was associated with resistance to apoptosis after IL\u20102 deprivation in Tax\u2010expressing CTLL\u20102 cells. Transient transfection assays showed that survivin promoter was transactivated by Tax, <jats:italic>via<\/jats:italic> the activation of NF\u2010\u03baB. Pharmacological NF\u2010\u03baB inhibition resulted in suppression of survivin expression and caused apoptosis of Tax\u2010expressing CTLL\u20102 cells. Our findings suggest that activated NF\u2010\u03baB signaling contributes directly to malignant progression of ATL by preventing apoptosis, acting through the prosurvival protein survivin. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.20954","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T19:41:57Z","timestamp":1109187717000},"page":"967-974","source":"Crossref","is-referenced-by-count":123,"title":["Transcriptional activation of survivin through the NF\u2010\u03baB pathway by human T\u2010cell leukemia virus type I tax"],"prefix":"10.1002","volume":"115","author":[{"given":"Hirochika","family":"Kawakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tokuhisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.11.4243.bloodjournal86114243"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00422.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2888190"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2990028"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.475"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02243-2"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.3.575"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/70487"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02902.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4708"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1994.10.1259"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8509"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.57"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1998.14.261"},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1128\/JVI.72.11.8852-8860.1998","article-title":"Human T\u2010cell lymphotropic\/leukemia virus type 1 Tax abrogates p53\u2010induced cell cycle arrest and apoptosis through its CREB\/ATF functional domain","volume":"72","author":"Mulloy JC","year":"1998","journal-title":"J Virol"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.2.1271-1277.1999"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/268154a0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.4.1069.1069"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190505"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.11.1875"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4445-4451.1997"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.5.2809"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.5.2083"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.9.5157"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(00)00142-1"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.8.3410.bloodjournal8783410"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb04767.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02554.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-917"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.15891"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.12.8136"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.225"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.7.4547"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.866"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9319"},{"key":"e_1_2_7_41_2","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1182\/blood.V91.12.4624","article-title":"Inhibition of nuclear factor \u03baB activation attenuates apoptosis resistance in lymphoid cells","volume":"91","author":"Jeremias I","year":"1998","journal-title":"Blood"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.34.21096"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11918"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.10.7981-7987.1999"},{"key":"e_1_2_7_46_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood.V96.1.275.013k43_275_281","article-title":"Bcl\u2010XL is up\u2010regulated by HTLV\u2010I and HTLV\u2010II in vitro and in ex vivo ATLL samples","volume":"96","author":"Nicot C","year":"2000","journal-title":"Blood"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011158021749"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0151"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.3.239"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14123"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/25141"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/70242"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.23.4363"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202657"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200112983"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2554"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-003-0255-2"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg277"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.04031"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00019-5"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4079"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.20954","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.20954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:16:54Z","timestamp":1697501814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.20954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,23]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,7,20]]}},"alternative-id":["10.1002\/ijc.20954"],"URL":"https:\/\/doi.org\/10.1002\/ijc.20954","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,23]]}}}