{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:49:53Z","timestamp":1790754593433,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T00:00:00Z","timestamp":1118707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection with <jats:italic>Opisthorchis viverrini<\/jats:italic> (OV) is associated with cholangiocarcinoma. OV is common in northeast Thailand, but less than 10% of the inhabitants develop cholangiocarcinoma. Animal experiments suggest that OV infection alone does not cause cholangiocarcinoma, and thus other environmental and genetic factors may play a role in causation. We conducted a population\u2010based case\u2010control study in which sex, age and place of residence were matched individually. Polymorphisms of <jats:italic>GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic> alone were not associated with risk for cholangiocarcinoma, while an elevated level of antibodies against OV (ELISA) \u22650.200 was the strongest risk indicator (odds ratio as compared to that &lt;0.200 = 27.09 [95% confidence interval (CI): 6.30\u2013116.57]. Compared to subjects who had a normal antibody range and the wild\u2010type <jats:italic>GSTM1<\/jats:italic> gene, those who had elevated antibodies had higher odds ratios of 12.32 (95% CI: 1.60\u201394.85) for wild\u2010type <jats:italic>GSTM1<\/jats:italic> and 23.53 (95% CI: 4.25\u2013130.31) for the null variant thereof, respectively. Past and current regular drinkers of alcohol had higher risk [odds ratio = 5.39 (95% CI: 1.11\u201326.06) and 4.82 (95% CI: 1.29\u201318.06), respectively]. Eating fermented products was an independent risk factor. Smokers or consumers of fermented fish had substantially increased risk if they were past or current drinkers. Infection with OV correlates strongly with cholangiocarcinoma, susceptibility to which may be possibly associated with <jats:italic>GSTM1<\/jats:italic> polymorphism. Alcohol may affect metabolic pathways of endogenous and exogenous nitrosamines. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21146","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T19:52:39Z","timestamp":1118778759000},"page":"854-860","source":"Crossref","is-referenced-by-count":146,"title":["Genetic and environmental determinants of risk for cholangiocarcinoma <i>via Opisthorchis viverrini<\/i> in a densely infested area in Nakhon Phanom, northeast Thailand"],"prefix":"10.1002","volume":"117","author":[{"given":"Satoshi","family":"Honjo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petcharin","family":"Srivatanakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hutcha","family":"Sriplung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Kikukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Hanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Todoroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adisorn","family":"Jedpiyawongse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pacharin","family":"Kittiwatanachot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banchob","family":"Sripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somyos","family":"Deerasamee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,14]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"537","article-title":"Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention","volume":"2","author":"Parkin DM","year":"1993","journal-title":"Cancer Epidemiol Biomarker Prev"},{"key":"e_1_2_6_3_2","series-title":"Cancer in Thailand Vol. II, 1992\u20131994 IARC Technical report","first-page":"135","author":"Deerasamee S","year":"1999"},{"key":"e_1_2_6_4_2","first-page":"121","article-title":"Infection with liver flukes (Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis)","volume":"61","author":"International agency for research on cancer","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)90009-4"},{"key":"e_1_2_6_6_2","first-page":"13","article-title":"Metabolism of xenobiotics and chemical carcinogenesis","author":"Lang M","year":"1999","journal-title":"IARC Sci Publ"},{"key":"e_1_2_6_7_2","first-page":"231","article-title":"The glutathione S\u2010transferases: influence of polymorphism on cancer susceptibility","author":"Strange RC","year":"1999","journal-title":"IARC Sci Publ"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480302"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00286.x"},{"key":"e_1_2_6_10_2","first-page":"4634","article-title":"Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini\u2010infected Syrian golden hamsters","volume":"38","author":"Thamavit W","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899196"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199706000-00003"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(99)00017-4"},{"key":"e_1_2_6_14_2","first-page":"501","article-title":"Effect of ethanol on nitrosamine metabolism and distribution. Implications for the role of nitrosamines in human cancer and for the influence of alcohol consumption on cancer incidence","author":"Swann PF","year":"1984","journal-title":"IARC Sci Publ"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(94)00089-1"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(96)04832-X"},{"key":"e_1_2_6_17_2","series-title":"The analysis of case\u2010control studies","volume-title":"Statistical methods in cancer research","author":"Breslow NE","year":"1980"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008915"},{"key":"e_1_2_6_19_2","unstructured":"Statacorp.Stata Statistical Software ed. Release 7.0 College Station TX: Stata Corporation 2001."},{"key":"e_1_2_6_20_2","first-page":"248","article-title":"Studies on the chemotherapy of human opisthorchiasis: effective dose of praziquantel in heavy infection","volume":"16","author":"Pungpak S","year":"1985","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90245-3"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.4.655.655"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00241-5"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90469-2"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018444902486"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i6.1187"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480606"},{"key":"e_1_2_6_30_2","volume-title":"Case\u2010control studies: design, conduct, analysis","author":"Schlesselman JJ","year":"1982"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940060408"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.21146","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.21146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:05:57Z","timestamp":1696892757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.21146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,14]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,12,10]]}},"alternative-id":["10.1002\/ijc.21146"],"URL":"https:\/\/doi.org\/10.1002\/ijc.21146","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,14]]}}}