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The short transcript lacks part of the 3\u2032UTR region regulating mRNA stability and has a longer half\u2010life. In our study, the contribution of each of these mRNAs to gene expression and cell proliferation has been investigated in mantle cell lymphoma (MCL), a B cell lymphoma characterized by a specific gene translocation resulting in enhanced expression of cyclin D1. A subset of MCL tumors with low levels of the long cyclin D1 transcript (cyclin D1 3\u2032UTR) was identified by quantitative PCR and by oligonucleotide array hybridization. This tumor\u2010subset had 3.4\u2010fold higher levels of the short form of cyclin D1 mRNA (<jats:italic>p<\/jats:italic> &lt; 0.0001) and had higher expression of cyclin D1 protein. Gene expression analysis identified a number of cell\u2010cycle regulatory genes as upregulated. There was a significant difference in frequencies of cyclin B1 (<jats:italic>p<\/jats:italic> = 0.0006) and cyclin A2 (<jats:italic>p<\/jats:italic> = 0.0006) positive cells that discriminated MCL with low cyclin D1 3\u2032UTR from other highly proliferative MCL. Among differentially expressed genes, there was a highly upregulated gene with homology to the group of cell\u2010cycle promoting E2F transcription partners, <jats:italic>E2F_TDP5<\/jats:italic>. Several of the upregulated genes, such as <jats:italic>TOP2A<\/jats:italic>, <jats:italic>AURORA A<\/jats:italic> and <jats:italic>RRM2<\/jats:italic> may influence a response to therapy. Identification of MCL with low cyclin D1 3\u2032UTR is important because it seems to be associated with shorter overall survival. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21166","type":"journal-article","created":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T18:47:51Z","timestamp":1116355671000},"page":"418-430","source":"Crossref","is-referenced-by-count":32,"title":["Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1"],"prefix":"10.1002","volume":"117","author":[{"given":"Birgitta","family":"Sander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Flygare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Porwit\u2010MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.I. 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