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Our aim was to explore the relationship between this polymorphism of the <jats:italic>BCRP<\/jats:italic> gene and the risk of renal cell carcinoma (RCC) development. For a case\u2010control study, DNA samples from 200 nonpapillary RCC patients and 200 healthy control subjects were analyzed using the TaqMan technique. The genotypic frequencies of the <jats:italic>BCRP<\/jats:italic> C421A polymorphism were compared between RCC patients and control subjects. The frequency of the <jats:italic>C\/C<\/jats:italic> genotype was significantly higher in RCC patients than in control subjects (age\u2010 and gender\u2010adjusted OR = 1.96, 95% CI 1.32\u20132.93). No associations were observed between the <jats:italic>BCRP<\/jats:italic> C421A polymorphism and clinicopathologic or epidemiologic factors, including age, gender, tumor grade, stage, cigarette smoking, family history of cancer and body mass index. Carriers with the <jats:italic>C\/C<\/jats:italic> genotype of the <jats:italic>BCRP<\/jats:italic> C421A polymorphism are at risk of developing nonpapillary RCC. These data suggest that <jats:italic>BCRP<\/jats:italic> is a candidate RCC susceptibility gene. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21187","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T17:46:34Z","timestamp":1116524794000},"page":"431-434","source":"Crossref","is-referenced-by-count":46,"title":["Association of the <i>BCRP<\/i> C421A polymorphism with nonpapillary renal cell 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