{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:09:53Z","timestamp":1770822593330,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2005,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Findings from a case\u2010control study of cutaneous malignant melanoma (CMM) in Queensland, Australia, suggest that melanomas exhibiting p53 immunostaining possess different risk factors from those of other melanomas. To further explore this hypothesis, a case\u2010only analysis of risk factors for p53 immunostaining with anti\u2010p53 MAb DO\u20107 was undertaken in 523 people diagnosed with CMM in Canada and Australia. Phenotypic factors and past sun exposure were measured using a self\u2010administered questionnaire and telephone interview. The presence of strong p53 staining (&gt;10% of cell nuclei positively stained <jats:italic>vs.<\/jats:italic> &lt;1% staining) was positively associated with some indicators of high cumulative sun exposure: lentigo maligna melanoma subtype (OR = 3.2 <jats:italic>vs.<\/jats:italic> superficial spreading subtype), melanoma location on the head and neck (OR = 2.8 <jats:italic>vs.<\/jats:italic> back), histopathologic evidence of solar elastosis (OR = 2.1) and previous diagnosis of nonmelanoma skin cancer (OR = 2.4). Strong staining was negatively associated with high nevus density on the back (OR = 0.2 for &gt;25 nevi <jats:italic>vs.<\/jats:italic> 0\u20133 nevi) and histologic evidence of a coexisting nevus (OR = 0.3). Other factors associated with strong p53 immunostaining include greater Breslow thickness (OR = 7.4 for &gt;4.00 <jats:italic>vs.<\/jats:italic> &lt;0.76 mm), male sex (OR = 2.2) and dense freckling (OR = 6.6 <jats:italic>vs.<\/jats:italic> few freckles). Of these, thickness, male sex, dense freckling, low nevus density on the back, histologic subtype and history of nonmelanoma skin cancer appeared to be independently associated with strong p53 staining. Our findings are consistent with the Queensland study in suggesting that variables indicating high accumulated sun exposure are positively associated with p53 staining and that an increased number of nevi is positively associated with its absence; they may reflect etiologic and pathogenetic heterogeneity in melanoma. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21196","type":"journal-article","created":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T18:47:30Z","timestamp":1116355650000},"page":"486-493","source":"Crossref","is-referenced-by-count":21,"title":["Etiologic factors associated with p53 immunostaining in cutaneousmalignant melanoma"],"prefix":"10.1002","volume":"117","author":[{"given":"Mark P.","family":"Purdue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"From","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriette J.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce K.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Kricker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil S.","family":"Klar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loraine D.","family":"Marrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Genes, Environment and Melanoma Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028709103888"},{"key":"e_1_2_6_3_2","first-page":"5036","article-title":"Incidence of cutaneous melanoma in the United States by histology with special reference to the face","volume":"48","author":"Newell GR","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.225"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<276::AID-IJC2>3.0.CO;2-S"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70133-Z"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70253-X"},{"key":"e_1_2_6_8_2","first-page":"831","article-title":"Cutaneous melanoma in women: anatomic distribution in relation to sun exposure and phenotype","volume":"4","author":"Cress RD","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052747"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6411.99"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910620406"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199904000-00012"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.806"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<843::AID-IJC8>3.0.CO;2-U"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200304000-00002"},{"key":"e_1_2_6_16_2","first-page":"99","article-title":"A note on the estimation of relative risks of rare genetic susceptibility markers","volume":"6","author":"Begg CB","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600411"},{"key":"e_1_2_6_18_2","first-page":"857","article-title":"Reproducibility of reported measurements of sun exposure in a case\u2010control study","volume":"7","author":"English DR","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10579"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/39.6.1709656"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680270077009"},{"key":"e_1_2_6_22_2","first-page":"2235","article-title":"Overexpression of p53 is a late event in the development of malignant melanoma","volume":"53","author":"Lassam NJ","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199512000-00001"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971021)74:5<535::AID-IJC10>3.0.CO;2-5"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010125"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70207-1"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(18)30768-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(99)00053-6"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12321071"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960621)69:3<174::AID-IJC4>3.0.CO;2-X"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980220)79:1<91::AID-IJC17>3.0.CO;2-K"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690147"},{"key":"e_1_2_6_33_2","first-page":"2480","article-title":"Association between DNA repair\u2010deficiency and high level of p53 mutations in melanoma of xeroderma pigmentosum","volume":"61","author":"Spatz A","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_34_2","first-page":"331","article-title":"Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm\u20102 overexpression","volume":"7","author":"Poremba C","year":"1995","journal-title":"Oncol Res"},{"key":"e_1_2_6_35_2","first-page":"7642","article-title":"HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma","volume":"61","author":"Polsky D","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.23.1803"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206445"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22225.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22523.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg123"},{"key":"e_1_2_6_41_2","first-page":"883","article-title":"Relevance of ultraviolet\u2010induced N\u2010ras oncogene point mutations in development of primary human cutaneous melanoma","volume":"149","author":"van Elsas A","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00376.x"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.21196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.21196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:33:38Z","timestamp":1697178818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.21196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,14]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,11,10]]}},"alternative-id":["10.1002\/ijc.21196"],"URL":"https:\/\/doi.org\/10.1002\/ijc.21196","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,14]]}}}