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To our knowledge, this is the first study on endogenous LIV\u20101 protein expression. Results of our study indicate that LIV\u20101 mRNA and protein expression levels are only weakly correlated, suggesting posttranscriptional regulatory mechanisms. Furthermore, LIV\u20101 mRNA quantity in combination with a positive ER status seem to represent a better marker than the progesterone receptor status according to the prognostic significance for relapse free survival (RFS). A negative correlation of LIV\u20101 protein levels with tumor size, grade and stage reflects an association of LIV\u20101 protein expression with less aggressive tumors. High LIV\u20101 protein expression seems to be associated with a longer relapse free and overall survival in breast cancer patients with invasive ductal carcinoma. This association, however, seems to be dependent from other prognostic markers. Our data suggest that LIV\u20101 is a promising candidate for a novel marker for breast cancer patients with better outcome. Furthermore, our study presents a revised cDNA sequence of LIV\u20101 and demonstrates the localization of endogenous <jats:italic>LIV\u20101<\/jats:italic> in the endoplasmic reticulum. (Supplementary material for this article can be found on the <jats:italic>International Journal of Cancer<\/jats:italic> website at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\/jpages\/0020-7136\/suppmat\/index.html\">http:\/\/www.interscience. wiley.com\/jpages\/0020\u20107136\/suppmat\/index.html<\/jats:ext-link>). \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21235","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T21:47:36Z","timestamp":1119995256000},"page":"961-973","source":"Crossref","is-referenced-by-count":68,"title":["Expression levels of the putative zinc transporter LIV\u20101 are associated with a better outcome of breast cancer patients"],"prefix":"10.1002","volume":"117","author":[{"given":"Grit","family":"Kasper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin A.","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sparbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Schwidetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda","family":"Casta\u00f1os\u2010V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(88)90105-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90543-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.271"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01807034"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216540050033087"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030478"},{"key":"e_1_2_6_8_2","first-page":"157","article-title":"Role of zinc in eukaryotic cells, zinc transporters and zinc\u2010containing proteins. 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