{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:28:36Z","timestamp":1785904116852,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T00:00:00Z","timestamp":1120694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Betulinic acid (BA), a pentacyclic triterpene of natural origin, effectively induces apoptosis in neuroectodermal tumors and was recently shown to be a potent trigger of cell death in human leukemia\u2010derived cell lines. To explore the potential of BA in the treatment of hematologic malignancies, we tested a panel of 10 Burkitt's lymphoma (BL)\u2010derived B\u2010cell lines for sensitivity to BA. The human Jurkat T leukemia cell line was included as a positive control. Our studies show that BA exerts cytotoxic effects in some of the BL cell lines tested, including DG75, a chemoresistant BL cell line. However, cell death was caspase\u2010independent, as evidenced by a lack of protection by zVAD\u2010fmk, a pancaspase inhibitor, and displayed signs of necrosis. Furthermore, BA\u2010induced caspase activation was seen to a minor extent in only 1 of the 10 BL cell lines tested (Ramos, a p53\u2010deficient cell line), but was readily detected in Jurkat cells. Together, these studies indicate that resistance to BA\u2010induced apoptosis is a common feature of BL\u2010derived cell lines. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21311","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T18:17:49Z","timestamp":1120760269000},"page":"246-252","source":"Crossref","is-referenced-by-count":18,"title":["Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma\u2010derived B\u2010cell lines"],"prefix":"10.1002","volume":"118","author":[{"given":"Maria B.","family":"Karpova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duangmanee","family":"Sanmun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Inge","family":"Henter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr 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