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We extended follow\u2010up of our earlier cohort study of Danish women with cosmetic breast implants by 7 years, yielding 30 years of follow\u2010up for women with longest implant duration. The study population consisted of women who underwent cosmetic breast implant surgery at private clinics of plastic surgery (<jats:italic>n<\/jats:italic> = 1,653) or public hospitals (<jats:italic>n<\/jats:italic> = 1,110), and a control group of women who attended private clinics for other plastic surgery (<jats:italic>n<\/jats:italic> = 1,736), between 1973\u201395. Cancer incidence through 2002 was ascertained using the Danish Cancer Registry. Risk evaluation was based on computation of standardized incidence ratios (SIR) and Cox proportional hazards models, adjusting for age, calendar period and reproductive history. We observed 163 cancers among women with breast implants compared to 136.7 expected based on general population rates (SIR = 1.2; 95% confidence interval [CI] = 1.0\u20131.4), during a mean follow\u2010up period of 14.4 years (range = 0\u201330 years). Women with breast implants experienced a reduced risk of breast cancer (SIR = 0.7; 95% CI = 0.5\u20131.0), and an increased risk of non\u2010melanoma skin cancer (SIR = 2.1; 95% CI = 1.5\u20132.7). Stratification by age at implantation, calendar year at implantation and time since implantation showed no clear trends, however, the statistical precision was limited in these analyses. When excluding non\u2010melanoma skin cancer, the SIR for cancer overall was 1.0 (95% CI = 0.8\u20131.2). With respect to other site\u2010specific cancers, no significantly increased or decreased SIR were observed. Similar results were found when directly comparing women who had implants at private clinics with women who attended private clinics for other plastic surgery, with rate ratios for cancer overall, breast cancer and non\u2010melanoma skin cancer of 1.1 (95% CI = 0.8\u20131.6), 0.7 (95% CI = 0.4\u20131.3) and 1.5 (95% CI = 0.8\u20132.7), respectively. In conclusion, our study lends further support to the accumulating evidence that silicone breast implants are not carcinogenic. Reasons for the consistently reported deficit of breast cancer among women with breast implants remain unclear, whereas increased exposure to sunlight may explain the excess occurrence of non\u2010melanoma skin cancer. We found no indication of delayed diagnosis of breast cancer due to the presence of breast implants. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21433","type":"journal-article","created":{"date-parts":[[2005,9,8]],"date-time":"2005-09-08T16:53:21Z","timestamp":1126198401000},"page":"998-1003","source":"Crossref","is-referenced-by-count":56,"title":["Cancer risk among Danish women with cosmetic breast implants"],"prefix":"10.1002","volume":"118","author":[{"given":"S\u00f8ren","family":"Friis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbet R.","family":"H\u00f6lmich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kj\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon P.","family":"Fryzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine F.","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen H.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"333","article-title":"Further studies of polymers as carcinogenic agents in animals","volume":"15","author":"Opppenheimer BS","year":"1955","journal-title":"Cancer Res"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000386014","article-title":"Silicate\u2010induced neoplasms","volume":"9","author":"Bryson G","year":"1967","journal-title":"Prog Exp Tumor Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198010000-00015"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)00211-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.14.1058"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196912000-00003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198401000-00009"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199506000-00012"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85226-8_41"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5858\/2003-127-e115-ALCLAI","article-title":"Anaplastic large cell lymphoma arising in a silicone breast implant capsule: a case report and review of the literature","volume":"127","author":"Sahoo S","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92021-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199204000-00010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506083322302"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199602000-00001"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199704001-00022"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406163302401"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970611)71:6<956::AID-IJC8>3.0.CO;2-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199709000-00032"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.156"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(98)90047-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001015)88:2<301::AID-IJC24>3.0.CO;2-G"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008941110816"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(00)00223-4"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.v12.i4.60"},{"key":"e_1_2_6_26_2","volume-title":"Safety of silicone breast implants. 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