{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:00:59Z","timestamp":1785189659780,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,8]],"date-time":"2005-09-08T00:00:00Z","timestamp":1126137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiotherapy is commonly used for treatment of malignant disease. As a consequence of radiotherapy, an increased risk of developing a second malignant neoplasm has been shown. However, little is known about the effects of radiation on developing sarcoma. The aim of this study was to examine the risk of developing a bone or soft tissue sarcoma after radiotherapy for a first primary cancer. The study population included all the patients with primary cancers of breast, cervix uteri, corpus uteri, lung, ovary, prostate, rectum and lymphoma diagnosed during 1953\u20132000 and identified from the Finnish Cancer Registry. Patients were followed up for subsequent sarcomas. The follow\u2010up yielded 1.5 million person\u2010years at risk and 147 sarcomas. Compared to the national incidence rates, after 10 years of follow\u2010up sarcoma risk was increased among patients who had received neither radiotherapy nor chemotherapy (standardised incidence ratio (SIR) 2.0, 95% CI 1.3\u20133.0), radiotherapy without chemotherapy (SIR 3.2, 95% CI 2.3\u20134.3), chemotherapy without radiotherapy (SIR 4.9, 95% CI 1.0\u201314.4), as well as combined radiotherapy and chemotherapy (SIR 3.4, 95% CI 0.4\u201312.5). For radiotherapy in ages below 55 the SIR was 4.2 (95% CI 2.9\u20135.8). In the adjusted regression analysis the rate ratio was 1.5 (95% CI 0.9\u20132.6) for the radiotherapy group. In conclusion, radiotherapy appears to be associated with an increased risk of developing sarcoma especially among younger patients. Further investigation is needed to clarify the dose\u2013response of the preceding ionizing radiation. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21456","type":"journal-article","created":{"date-parts":[[2005,9,8]],"date-time":"2005-09-08T16:49:21Z","timestamp":1126198161000},"page":"1017-1021","source":"Crossref","is-referenced-by-count":79,"title":["Incidence of bone and soft tissue sarcoma after radiotherapy: A cohort study of 295,712 Finnish cancer patients"],"prefix":"10.1002","volume":"118","author":[{"given":"Anna","family":"Virtanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Pukkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anssi","family":"Auvinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_5_2_2","series-title":"IARC monographs on the evaluation of carcinogenic risks to humans","first-page":"138","volume-title":"Ionizing radiation, part 1: X\u2010 and gamma (\u03b3) radiation and neutrons","author":"International Agency for Research on Cancer","year":"2000"},{"key":"e_1_2_5_3_2","first-page":"400","volume-title":"Report to the General Assembly with scientific annexes: Sources and effects of ionizing radiation","author":"UNSCEAR","year":"2000"},{"key":"e_1_2_5_4_2","first-page":"40","volume-title":"Epidemiological evaluation of radiation\u2010induced cancer","author":"UNSCEAR","year":"1999"},{"key":"e_1_2_5_5_2","first-page":"8","volume-title":"Cancer incidence in Finland 1998 and 1999: Cancer statistics of the National Research and Development Centre for Welfare and Health","author":"Finnish Cancer Registry","year":"2002"},{"key":"e_1_2_5_6_2","first-page":"8","volume-title":"Cancer incidence in Finland 2000 and 2001: Cancer statistics of the National Research and Development Centre for Welfare and Health","author":"Finnish Cancer Registry","year":"2003"},{"key":"e_1_2_5_7_2","first-page":"9","volume-title":"WHO Classification of Tumours Pathology and Genetics. 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