{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:40:39Z","timestamp":1791218439001,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T00:00:00Z","timestamp":1128902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allelic loss of chromosome 8p21\u201322 is a frequent event in various human cancers including mantle cell lymphoma (MCL), prostate cancer, head and neck squamous cell carcinoma (HNSCC) and bladder cancer. The <jats:italic>tumor necrosis factor\u2010related apoptosis inducing ligand<\/jats:italic> (TRAIL) receptors, including <jats:italic>TNFRSF10A<\/jats:italic> and <jats:italic>TNFRSF10B<\/jats:italic>, are located within this chromosomal region. Since recent studies demonstrate that chronic lymphocytic leukemia (CLL) and prostate cells are TRAIL induced apoptosis, TRAIL\u2010receptors are strong tumor suppressor candidate genes in human cancers exhibiting loss of chromosomal material in 8p21.3. However, no mutation of the TRAIL receptor genes has been reported in CLL, MCL, prostate cancer, HNSCC so far. In this study we analyzed the complete coding region of <jats:italic>TNFRSF10A<\/jats:italic> and <jats:italic>TNFRSF10B<\/jats:italic> in a series of 32 MCL and 101 CLL samples and detected a single nucleotide polymorphism (SNP) in <jats:italic>TNFRSF10A<\/jats:italic> (A683C) with tumor specific allele distribution. We examined allele distribution in 395 samples of different tumor entities (prostate cancer, <jats:italic>n<\/jats:italic> = 43; HNSCC, <jats:italic>n<\/jats:italic> = 40; bladder cancer, <jats:italic>n<\/jats:italic> = 179) and compared them to 137 samples from healthy probands. We found the rare allele of <jats:italic>TNFRSF10A<\/jats:italic> is more frequent in CLL, MCL, prostate cancer, bladder cancer and HNSCC. The A683C polymorphism did not cosegregate with other <jats:italic>TNFRSF10A<\/jats:italic> polymorphisms previously described. Thus screening for 683A\u2192C nucleotide exchanges may become important in diagnosis and\/or treatment of these malignancies. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21502","type":"journal-article","created":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T18:16:31Z","timestamp":1128968191000},"page":"1831-1835","source":"Crossref","is-referenced-by-count":38,"title":["Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder 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