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Both protein products of <jats:italic>TSC1<\/jats:italic> and <jats:italic>TSC2<\/jats:italic> form an intracellular complex exerting GTPase\u2010activating (GAP) activity towards a small G protein, Ras homologue enriched in brain (Rheb). Inhibition of Rheb is important for the regulation of mTOR pathway, while mutation of hamartin or tuberin results in uncontrolled cell cycle progression. Tuberin, possessing the Rheb\u2010GAP domain, is phosphorylated by several kinases that confer the signals of growth factor stimulation or low cellular energy levels. Such a modification of tuberin influences its activity within the complex with hamartin and positively or negatively modulates mTOR\u2010regulated protein translation and cellular proliferation. Current article describes biochemical properties of hamartin and tuberin, their known regulatory phosphorylation sites and binding partners. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21542","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T17:49:42Z","timestamp":1128448182000},"page":"1-5","source":"Crossref","is-referenced-by-count":72,"title":["Hamartin and tuberin: Working together for tumour 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